DegronMD - Q9NVP1(DDX18)

DDX18

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F615L	TCGA-76-6664	GBM	TCGA	VPPFVD	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.2778
p.F615L	DO11310	GBM	ICGC	VPPFVD	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.2778
p.P619S	TCGA-A5-A0G2	UCEC	TCGA	VPPFVD	LIG_APCC_ABBA_1	617:622	Mutation altering degron motif	0.6752
p.P619S	DO41235	UCEC	ICGC	VPPFVD	LIG_APCC_ABBA_1	617:622	Mutation altering degron motif	0.6752
p.V609A	TCGA-DA-A95Y	SKCM	TCGA	VPPFVD	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1111
p.V609A	DO223908	SKCM	ICGC	VPPFVD	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1111
p.Q608R	TCGA-F4-6570	COAD	TCGA	VPPFVD	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.0833
p.Q608R	DO10443	COAD	ICGC	VPPFVD	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.0833
p.K631N	DO229029	LICA	ICGC	VPPFVD	LIG_APCC_ABBA_1	617:622	Mutation substituting flanking lysine	0.1944
p.S627I	DO229028	LICA	ICGC	VPPFVD	LIG_APCC_ABBA_1	617:622	Mutation blocking phosphorylation signal	0.6389
p.V609F	DO229041	LICA	ICGC	VPPFVD	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc