DegronMD

Uniprot ID: Q9NVP1

Source protein: ATP-dependent RNA helicase DDX18

Source gene: DDX18

Class: LIG_APCC_ABBA_1

Location: 617:622

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.801

ASA_SCORE: 62.3833

COIL: 0.9035

CONS_SCORE: 0.5208

DSS_SCORE: 0.2015

HELIX: 0.0247

FCONS_SCORE: 1.3453

RIG_SCORE: 0.8453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F615L	TCGA-76-6664	GBM	TCGA	VPPFVD	LIG_APCC_ABBA_1	0.2778
p.F615L	DO11310	GBM	ICGC	VPPFVD	LIG_APCC_ABBA_1	0.2778
p.P619S	TCGA-A5-A0G2	UCEC	TCGA	VPPFVD	LIG_APCC_ABBA_1	0.6752
p.P619S	DO41235	UCEC	ICGC	VPPFVD	LIG_APCC_ABBA_1	0.6752
p.V609A	TCGA-DA-A95Y	SKCM	TCGA	VPPFVD	LIG_APCC_ABBA_1	0.1111
p.V609A	DO223908	SKCM	ICGC	VPPFVD	LIG_APCC_ABBA_1	0.1111
p.Q608R	TCGA-F4-6570	COAD	TCGA	VPPFVD	LIG_APCC_ABBA_1	0.0833
p.Q608R	DO10443	COAD	ICGC	VPPFVD	LIG_APCC_ABBA_1	0.0833
p.K631N	DO229029	LICA	ICGC	VPPFVD	LIG_APCC_ABBA_1	0.1944
p.S627I	DO229028	LICA	ICGC	VPPFVD	LIG_APCC_ABBA_1	0.6389
p.V609F	DO229041	LICA	ICGC	VPPFVD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVP1	ATP-dependent RNA helicase DDX18	LIG_APCC_ABBA_1	617:622	VPPFVD	APC,CDC20,FZR1	0.801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons