DegronMD - Q9NVR5(DNAAF2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R202S	TCGA-56-7822	LUSC	TCGA	LRTPLPGVI	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7427
p.R202S	DO26638	LUSC	ICGC	LRTPLPGVI	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7427
p.T203K	TCGA-77-8139	LUSC	TCGA	LRTPLPGVI	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.6195
p.T203K	DO26524	LUSC	ICGC	LRTPLPGVI	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.6195
p.K218N	DO220827	BRCA	ICGC	LRTPLPGVI	DEG_APCC_DBOX_1	201:209	Mutation substituting flanking lysine	0.1944
p.G215R	SIDM00217	Colorectal Carcinoma	GDSC	LRTPLPGVI	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1667
p.G215R	ACH-000999	Colon/Colorectal Cancer	CCLE	LRTPLPGVI	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1667
p.G215R	SNU-1040	large intestine	COSMIC	LRTPLPGVI	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1667
p.A199E	ACH-001063	Ovarian Cancer	CCLE	LRTPLPGVI	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons