DegronMD

Uniprot ID: Q9NVR5

Source protein: Protein kintoun

Source gene: DNAAF2

Class: DEG_APCC_DBOX_1

Location: 201:209

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.995

ASA_SCORE: 64.8111

COIL: 0.7609

CONS_SCORE: 0.4504

DSS_SCORE: 0.5087

HELIX: 0.0356

FCONS_SCORE: 0.9547

RIG_SCORE: 0.7164

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R202S	TCGA-56-7822	LUSC	TCGA	LRTPLPGVI	DEG_APCC_DBOX_1	0.7427
p.R202S	DO26638	LUSC	ICGC	LRTPLPGVI	DEG_APCC_DBOX_1	0.7427
p.T203K	TCGA-77-8139	LUSC	TCGA	LRTPLPGVI	DEG_APCC_DBOX_1	0.6195
p.T203K	DO26524	LUSC	ICGC	LRTPLPGVI	DEG_APCC_DBOX_1	0.6195
p.A199E	ACH-001063	Ovarian Cancer	CCLE	LRTPLPGVI	DEG_APCC_DBOX_1	0.2778
p.K218N	DO220827	BRCA	ICGC	LRTPLPGVI	DEG_APCC_DBOX_1	0.1944
p.G215R	SIDM00217	Colorectal Carcinoma	GDSC	LRTPLPGVI	DEG_APCC_DBOX_1	0.1667
p.G215R	ACH-000999	Colon/Colorectal Cancer	CCLE	LRTPLPGVI	DEG_APCC_DBOX_1	0.1667
p.G215R	SNU-1040	large_intestine	COSMIC	LRTPLPGVI	DEG_APCC_DBOX_1	0.1667

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVR5	Protein kintoun	DEG_APCC_DBOX_1	201:209	LRTPLPGVI	APC,CDC20,FZR1	0.995	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons