DegronMD - Q9NW61(PLEKHJ1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P130A	TCGA-CV-5439	HNSC	TCGA	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0556
p.P130A	DO14200	HNSC	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0556
p.F134L	TCGA-DA-A1IA	SKCM	TCGA	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1667
p.F134L	DO38022	SKCM	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1667
p.R141H	DO234161	ESAD	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.8244
p.P147S	DO234464	ESAD	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.6752
p.E138K	DO233288	GACA	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.2778
p.G132R	DO222898	MELA	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1111
p.A149V	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.3056
p.A149V	ACH-000161	Lung Cancer	CCLE	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.3056
p.A149V	COR-L105	lung	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.3056
p.L131P	SIDM01045	Endometrial Carcinoma	GDSC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0833
p.L131P	ACH-000978	Endometrial/Uterine Cancer	CCLE	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0833
p.L131P	EN	endometrium	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0833
p.I136V	SIDM01664	Prostate Carcinoma	GDSC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.2222
p.I136V	ACH-000952	Prostate Cancer	CCLE	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.2222
p.A153T	FTC-133	thyroid	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1944
p.A150V	COR-L105	lung	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.2778
p.E144V	PF-382	haematopoietic and lymphoid tissue	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.7693
p.M152I	NCC021	kidney	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.2222
p.L132P	EN	endometrium	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1111

Kaplan plot for PLEKHJ1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHJ1

UniProt ID: Q9NW61

Entrez ID: 55111

Protein name: Pleckstrin homology domain-containing family J member 1 (PH domain-containing family J member 1) (Guanine nucleotide-releasing protein x)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHJ1 in