DegronMD

Uniprot ID: Q9NW61

Source protein: Pleckstrin homology domain-containing family J member 1

Source gene: PLEKHJ1

Class: DEG_APCC_DBOX_1

Location: 140:148

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5536

ASA_SCORE: 86.9667

COIL: 0.5641

CONS_SCORE: 0.3923

DSS_SCORE: 0.5497

HELIX: 0.348

FCONS_SCORE: 0.7517

RIG_SCORE: 0.7753

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P130A	TCGA-CV-5439	HNSC	TCGA	ARFQLSGLQ	DEG_APCC_DBOX_1	0.0556
p.P130A	DO14200	HNSC	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.0556
p.F134L	TCGA-DA-A1IA	SKCM	TCGA	ARFQLSGLQ	DEG_APCC_DBOX_1	0.1667
p.F134L	DO38022	SKCM	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.1667
p.R141H	DO234161	ESAD	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.8244
p.P147S	DO234464	ESAD	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.6752
p.E138K	DO233288	GACA	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.2778
p.G132R	DO222898	MELA	ICGC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.1111
p.A149V	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.3056
p.A149V	ACH-000161	Lung Cancer	CCLE	ARFQLSGLQ	DEG_APCC_DBOX_1	0.3056
p.A149V	COR-L105	lung	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.3056
p.L131P	SIDM01045	Endometrial Carcinoma	GDSC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.0833
p.L131P	ACH-000978	Endometrial/Uterine Cancer	CCLE	ARFQLSGLQ	DEG_APCC_DBOX_1	0.0833
p.L131P	EN	endometrium	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.0833
p.I136V	SIDM01664	Prostate Carcinoma	GDSC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.2222
p.I136V	ACH-000952	Prostate Cancer	CCLE	ARFQLSGLQ	DEG_APCC_DBOX_1	0.2222
p.A153T	FTC-133	thyroid	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.1944
p.A150V	COR-L105	lung	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.2778
p.E144V	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.7693
p.M152I	NCC021	kidney	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.2222
p.L132P	EN	endometrium	COSMIC	ARFQLSGLQ	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW61	Pleckstrin homology domain-containing family J member 1	DEG_APCC_DBOX_1	140:148	ARFQLSGLQ	APC,CDC20,FZR1	0.5536	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons