DegronMD - Q9NW82(WDR70)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E541Q	TCGA-77-7337	LUSC	TCGA	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation altering degron motif	0.6744
p.E541Q	DO27445	LUSC	ICGC	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation altering degron motif	0.6744
p.T547A	TCGA-D6-A74Q	HNSC	TCGA	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.1667
p.T547A	DO52087	HNSC	ICGC	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.1667
p.P542L	TCGA-LN-A4A5	ESCA	TCGA	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.3056
p.T532I	TCGA-NC-A5HH	LUSC	TCGA	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.2222
p.T532I	DO219187	LUSC	ICGC	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.2222
p.R540C	TCGA-ZG-A8QX	PRAD	TCGA	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation altering degron motif	0.719
p.R540C	DO51448	PRAD	ICGC	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation altering degron motif	0.719
p.A535V	DO229119	PRAD	ICGC	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.3056
p.L551V	DO229229	THCA	ICGC	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.0556
p.R540H	SIDM00373	Endometrial Carcinoma	GDSC	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation altering degron motif	0.7133
p.R540H	ACH-000974	Endometrial/Uterine Cancer	CCLE	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation altering degron motif	0.7133
p.R540H	ACH-002026	Endometrial/Uterine Cancer	CCLE	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation altering degron motif	0.7133
p.R540H	SNG-M	endometrium	COSMIC	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation altering degron motif	0.7133
p.D528H	SIDM00481	Ovarian Carcinoma	GDSC	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.1111
p.D528H	ACH-000116	Ovarian Cancer	CCLE	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.1111
p.D528H	OAW-28	ovary	COSMIC	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.1111
p.Q527R	SIDM01609	Endometrial Carcinoma	GDSC	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.0833
p.Q527R	ACH-000972	Endometrial/Uterine Cancer	CCLE	LPMFRE	LIG_APCC_ABBA_1	536:541	Mutation rewiring degron network	0.0833

Kaplan plot for WDR70 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR70

UniProt ID: Q9NW82

Entrez ID: 55100

Protein name: WD repeat-containing protein 70

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for WDR70 in