DegronMD

Uniprot ID: Q9NW82

Source protein: WD repeat-containing protein 70

Source gene: WDR70

Class: LIG_APCC_ABBA_1

Location: 536:541

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9955

ASA_SCORE: 67.25

COIL: 0.6927

CONS_SCORE: 0.5005

DSS_SCORE: 0.593

HELIX: 0.2632

FCONS_SCORE: 1.2661

RIG_SCORE: 0.7447

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E541Q	TCGA-77-7337	LUSC	TCGA	LPMFRE	LIG_APCC_ABBA_1	0.6744
p.E541Q	DO27445	LUSC	ICGC	LPMFRE	LIG_APCC_ABBA_1	0.6744
p.T547A	TCGA-D6-A74Q	HNSC	TCGA	LPMFRE	LIG_APCC_ABBA_1	0.1667
p.T547A	DO52087	HNSC	ICGC	LPMFRE	LIG_APCC_ABBA_1	0.1667
p.P542L	TCGA-LN-A4A5	ESCA	TCGA	LPMFRE	LIG_APCC_ABBA_1	0.3056
p.T532I	TCGA-NC-A5HH	LUSC	TCGA	LPMFRE	LIG_APCC_ABBA_1	0.2222
p.T532I	DO219187	LUSC	ICGC	LPMFRE	LIG_APCC_ABBA_1	0.2222
p.R540C	TCGA-ZG-A8QX	PRAD	TCGA	LPMFRE	LIG_APCC_ABBA_1	0.719
p.R540C	DO51448	PRAD	ICGC	LPMFRE	LIG_APCC_ABBA_1	0.719
p.A535V	DO229119	PRAD	ICGC	LPMFRE	LIG_APCC_ABBA_1	0.3056
p.L551V	DO229229	THCA	ICGC	LPMFRE	LIG_APCC_ABBA_1	0.0556
p.R540H	SIDM00373	Endometrial Carcinoma	GDSC	LPMFRE	LIG_APCC_ABBA_1	0.7133
p.R540H	ACH-000974	Endometrial/Uterine Cancer	CCLE	LPMFRE	LIG_APCC_ABBA_1	0.7133
p.R540H	ACH-002026	Endometrial/Uterine Cancer	CCLE	LPMFRE	LIG_APCC_ABBA_1	0.7133
p.R540H	SNG-M	endometrium	COSMIC	LPMFRE	LIG_APCC_ABBA_1	0.7133
p.D528H	SIDM00481	Ovarian Carcinoma	GDSC	LPMFRE	LIG_APCC_ABBA_1	0.1111
p.D528H	ACH-000116	Ovarian Cancer	CCLE	LPMFRE	LIG_APCC_ABBA_1	0.1111
p.D528H	OAW-28	ovary	COSMIC	LPMFRE	LIG_APCC_ABBA_1	0.1111
p.Q527R	SIDM01609	Endometrial Carcinoma	GDSC	LPMFRE	LIG_APCC_ABBA_1	0.0833
p.Q527R	ACH-000972	Endometrial/Uterine Cancer	CCLE	LPMFRE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW82	WD repeat-containing protein 70	LIG_APCC_ABBA_1	536:541	LPMFRE	APC,CDC20,FZR1	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons