DegronMD - Q9NWS8(RMND1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q155R	TCGA-BS-A0UJ	UCEC	TCGA	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.2778
p.Q155R	DO42745	UCEC	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.2778
p.S165C	TCGA-MV-A51V	BLCA	TCGA	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation altering degron motif	0.643
p.S165C	DO474	BLCA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation altering degron motif	0.643
p.R168T	DO219049	BLCA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.25
p.L154F	DO227947	BRCA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.25
p.L154F	DO37851	SKCM	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.25
p.S155R	DO229013	COCA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.2778
p.F164L	DO229029	LICA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation altering degron motif	0.6981
p.T161N	DO229027	LICA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation altering degron motif	0.7055
p.N170K	DO228322	MALY	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.1944
p.S156L	DO31260	OV	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.3056
p.Y175H	DO42729	UCEC	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.0556
p.A175S	SIDM00449	B-Lymphoblastic Leukemia	GDSC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.0556
p.A175S	ACH-000922	Leukemia	CCLE	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.0556
p.A175S	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.0556
p.S157P	SIDM00217	Colorectal Carcinoma	GDSC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation altering degron motif	0.5641
p.S157P	ACH-000999	Colon/Colorectal Cancer	CCLE	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation altering degron motif	0.5641
p.S157P	SNU-1040	large intestine	COSMIC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation altering degron motif	0.5641
p.S151F	SIDM01083	Oral Cavity Carcinoma	GDSC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.1667
p.S151F	ACH-000254	Head and Neck Cancer	CCLE	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.1667
p.S151F	SCC-15	upper aerodigestive tract	COSMIC	SRTNLPVLS	DEG_APCC_DBOX_1	157:165	Mutation rewiring degron network	0.1667

Kaplan plot for RMND1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RMND1

UniProt ID: Q9NWS8

Entrez ID: 55005

Protein name: Required for meiotic nuclear division protein 1 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RMND1 in