DegronMD

Uniprot ID: Q9NWS8

Source protein: Required for meiotic nuclear division protein 1 homolog

Source gene: RMND1

Class: DEG_APCC_DBOX_1

Location: 157:165

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8094

ASA_SCORE: 87.7333

COIL: 0.8763

CONS_SCORE: 0.2376

DSS_SCORE: 0.4729

HELIX: 0.0722

FCONS_SCORE: 0.7733

RIG_SCORE: 0.7233

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q155R	TCGA-BS-A0UJ	UCEC	TCGA	SRTNLPVLS	DEG_APCC_DBOX_1	0.2778
p.Q155R	DO42745	UCEC	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	0.2778
p.S165C	TCGA-MV-A51V	BLCA	TCGA	SRTNLPVLS	DEG_APCC_DBOX_1	0.643
p.S165C	DO474	BLCA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	0.643
p.R168T	DO219049	BLCA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	0.25
p.L154F	DO227947	BRCA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	0.25
p.L154F	DO37851	SKCM	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	0.25
p.S155R	DO229013	COCA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	0.2778
p.F164L	DO229029	LICA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	0.6981
p.T161N	DO229027	LICA	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	0.7055
p.N170K	DO228322	MALY	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	0.1944
p.S156L	DO31260	OV	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	0.3056
p.Y175H	DO42729	UCEC	ICGC	SRTNLPVLS	DEG_APCC_DBOX_1	0.0556
p.A175S	SIDM00449	B-Lymphoblastic Leukemia	GDSC	SRTNLPVLS	DEG_APCC_DBOX_1	0.0556
p.A175S	ACH-000922	Leukemia	CCLE	SRTNLPVLS	DEG_APCC_DBOX_1	0.0556
p.A175S	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	SRTNLPVLS	DEG_APCC_DBOX_1	0.0556
p.S157P	SIDM00217	Colorectal Carcinoma	GDSC	SRTNLPVLS	DEG_APCC_DBOX_1	0.5641
p.S157P	ACH-000999	Colon/Colorectal Cancer	CCLE	SRTNLPVLS	DEG_APCC_DBOX_1	0.5641
p.S157P	SNU-1040	large_intestine	COSMIC	SRTNLPVLS	DEG_APCC_DBOX_1	0.5641
p.S151F	SIDM01083	Oral Cavity Carcinoma	GDSC	SRTNLPVLS	DEG_APCC_DBOX_1	0.1667
p.S151F	ACH-000254	Head and Neck Cancer	CCLE	SRTNLPVLS	DEG_APCC_DBOX_1	0.1667
p.S151F	SCC-15	upper_aerodigestive_tract	COSMIC	SRTNLPVLS	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NWS8	Required for meiotic nuclear division protein 1 homolog	DEG_APCC_DBOX_1	157:165	SRTNLPVLS	APC,CDC20,FZR1	0.8094	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons