DegronMD - Q9NX36(DNAJC28)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P80S	TCGA-06-5416	GBM	TCGA	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation rewiring degron network	0.3056
p.P80S	DO10880	GBM	ICGC	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation rewiring degron network	0.3056
p.D88H	TCGA-60-2707	LUSC	TCGA	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation rewiring degron network	0.2778
p.D88H	DO26926	LUSC	ICGC	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation rewiring degron network	0.2778
p.K76N	TCGA-CA-6717	COAD	TCGA	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation substituting flanking lysine	0.3056
p.K76N	DO8264	COAD	ICGC	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation substituting flanking lysine	0.3056
p.N85T	TCGA-E6-A1LX	UCEC	TCGA	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation altering degron motif	0.5944
p.N85T	DO41020	UCEC	ICGC	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation altering degron motif	0.5944
p.E96Q	TCGA-QK-A6II	HNSC	TCGA	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation rewiring degron network	0.0556
p.E96Q	DO50006	HNSC	ICGC	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation rewiring degron network	0.0556
p.S89F	DO50671	ORCA	ICGC	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation rewiring degron network	0.25
p.T86I	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation altering degron motif	0.7078
p.L74F	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation rewiring degron network	0.1389
p.L74F	ACH-000717	Esophageal Cancer	CCLE	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation rewiring degron network	0.1389
p.L74F	COLO-680N	oesophagus	COSMIC	DSGSNT	DEG_SCF_TRCP1_1	81:86	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons