DegronMD

Uniprot ID: Q9NX36

Source protein: DnaJ homolog subfamily C member 28

Source gene: DNAJC28

Class: DEG_SCF_TRCP1_1

Location: 81:86

E3 ligase: BTRC

DEGRON score: 0.9582

ASA_SCORE: 79.7667

COIL: 0.8327

CONS_SCORE: 0.6243

DSS_SCORE: 0.4189

HELIX: 0.1498

FCONS_SCORE: 1.0478

RIG_SCORE: 0.618

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P80S	TCGA-06-5416	GBM	TCGA	DSGSNT	DEG_SCF_TRCP1_1	0.3056
p.P80S	DO10880	GBM	ICGC	DSGSNT	DEG_SCF_TRCP1_1	0.3056
p.D88H	TCGA-60-2707	LUSC	TCGA	DSGSNT	DEG_SCF_TRCP1_1	0.2778
p.D88H	DO26926	LUSC	ICGC	DSGSNT	DEG_SCF_TRCP1_1	0.2778
p.K76N	TCGA-CA-6717	COAD	TCGA	DSGSNT	DEG_SCF_TRCP1_1	0.3056
p.K76N	DO8264	COAD	ICGC	DSGSNT	DEG_SCF_TRCP1_1	0.3056
p.N85T	TCGA-E6-A1LX	UCEC	TCGA	DSGSNT	DEG_SCF_TRCP1_1	0.5944
p.N85T	DO41020	UCEC	ICGC	DSGSNT	DEG_SCF_TRCP1_1	0.5944
p.E96Q	TCGA-QK-A6II	HNSC	TCGA	DSGSNT	DEG_SCF_TRCP1_1	0.0556
p.E96Q	DO50006	HNSC	ICGC	DSGSNT	DEG_SCF_TRCP1_1	0.0556
p.S89F	DO50671	ORCA	ICGC	DSGSNT	DEG_SCF_TRCP1_1	0.25
p.T86I	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	DSGSNT	DEG_SCF_TRCP1_1	0.7078
p.L74F	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DSGSNT	DEG_SCF_TRCP1_1	0.1389
p.L74F	ACH-000717	Esophageal Cancer	CCLE	DSGSNT	DEG_SCF_TRCP1_1	0.1389
p.L74F	COLO-680N	oesophagus	COSMIC	DSGSNT	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NX36	DnaJ homolog subfamily C member 28	DEG_SCF_TRCP1_1	81:86	DSGSNT	BTRC	0.9582	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons