DegronMD - Q9NX95(SYBU)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M207L	TCGA-A5-A0G9	UCEC	TCGA	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.2778
p.R210M	TCGA-A6-6781	COAD	TCGA	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.8632
p.Q212P	TCGA-IN-8663	STAD	TCGA	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.5924
p.R215M	DO8447	COAD	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.8632
p.P225H	DO229015	LICA	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.1111
p.R205Q	DO23354	LINC	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.2222
p.S202A	DO45322	LUAD	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation blocking ubiquitination signal	0.5833
p.S211P	DO232761	PBCA	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.6752
p.Q217P	DO47805	STAD	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.7035
p.M212L	DO42304	UCEC	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.711
p.M207V	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.2778
p.M207V	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.2778
p.N211K	SIDM00212	Glioblastoma	GDSC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.5806
p.N211K	CAS-1	central nervous system	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.5806
p.P224T	SIDM00934	Pancreatic Carcinoma	GDSC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.1389
p.P199Q	SIDM01170	Ovarian Carcinoma	GDSC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.0556
p.P199Q	TOV-112D	ovary	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.0556
p.N210K	ACH-000464	Brain Cancer	CCLE	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.6918
p.N210K	CAS-1	central nervous system	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.6918
p.M206V	ACH-000697	Lymphoma	CCLE	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.25
p.M206V	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.25
p.A207P	SNU-C5	large intestine	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.2778
p.M212V	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.7208
p.Q226R	LS-411N	large intestine	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation blocking phosphorylation signal	0.5278
p.N208K	CAS-1	central nervous system	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.3056
p.M204V	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.1944
p.N216K	CAS-1	central nervous system	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.6918
p.V210A	EN	endometrium	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.6936
p.P204Q	TOV-112D	ovary	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.1944

Kaplan plot for SYBU in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYBU

UniProt ID: Q9NX95

Entrez ID: 55638

Protein name: Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYBU in