DegronMD

Uniprot ID: Q9NX95

Source protein: Syntabulin

Source gene: SYBU

Class: DEG_APCC_DBOX_1

Location: 209:217

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8707

ASA_SCORE: 93.6556

COIL: 0.8588

CONS_SCORE: 0.613

DSS_SCORE: 0.5455

HELIX: 0.1007

FCONS_SCORE: 0.8997

RIG_SCORE: 0.7039

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M207L	TCGA-A5-A0G9	UCEC	TCGA	CRNQLSPVN	DEG_APCC_DBOX_1	0.2778
p.R210M	TCGA-A6-6781	COAD	TCGA	CRNQLSPVN	DEG_APCC_DBOX_1	0.8632
p.Q212P	TCGA-IN-8663	STAD	TCGA	CRNQLSPVN	DEG_APCC_DBOX_1	0.5924
p.R215M	DO8447	COAD	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	0.8632
p.P225H	DO229015	LICA	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	0.1111
p.R205Q	DO23354	LINC	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	0.2222
p.S202A	DO45322	LUAD	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	0.5833
p.S211P	DO232761	PBCA	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	0.6752
p.Q217P	DO47805	STAD	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	0.7035
p.M212L	DO42304	UCEC	ICGC	CRNQLSPVN	DEG_APCC_DBOX_1	0.711
p.M207V	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRNQLSPVN	DEG_APCC_DBOX_1	0.2778
p.M207V	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.2778
p.N211K	SIDM00212	Glioblastoma	GDSC	CRNQLSPVN	DEG_APCC_DBOX_1	0.5806
p.N211K	CAS-1	central_nervous_system	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.5806
p.P224T	SIDM00934	Pancreatic Carcinoma	GDSC	CRNQLSPVN	DEG_APCC_DBOX_1	0.1389
p.P199Q	SIDM01170	Ovarian Carcinoma	GDSC	CRNQLSPVN	DEG_APCC_DBOX_1	0.0556
p.P199Q	TOV-112D	ovary	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.0556
p.N210K	ACH-000464	Brain Cancer	CCLE	CRNQLSPVN	DEG_APCC_DBOX_1	0.6918
p.N210K	CAS-1	central_nervous_system	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.6918
p.M206V	ACH-000697	Lymphoma	CCLE	CRNQLSPVN	DEG_APCC_DBOX_1	0.25
p.M206V	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.25
p.A207P	SNU-C5	large_intestine	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.2778
p.M212V	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.7208
p.Q226R	LS-411N	large_intestine	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.5278
p.N208K	CAS-1	central_nervous_system	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.3056
p.M204V	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.1944
p.N216K	CAS-1	central_nervous_system	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.6918
p.V210A	EN	endometrium	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.6936
p.P204Q	TOV-112D	ovary	COSMIC	CRNQLSPVN	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CRNQLSPVN

Degron related mutations and impact score

Drug responses associated with SYBU mutations

All proteins holding degron of CRNQLSPVN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NX95	Syntabulin	DEG_APCC_DBOX_1	209:217	CRNQLSPVN	APC,CDC20,FZR1	0.8707	More...