DegronMD - Q9NXF7(DCAF16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S29Y	TCGA-AJ-A3EK	UCEC	TCGA	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.712
p.S29Y	TCGA-AX-A2HC	UCEC	TCGA	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.712
p.S29Y	DO41584	UCEC	ICGC	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.712
p.S29Y	DO41572	UCEC	ICGC	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.712
p.Y24C	TCGA-BB-4223	HNSC	TCGA	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.2778
p.Y24C	DO15607	HNSC	ICGC	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.2778
p.G30V	TCGA-CK-6746	COAD	TCGA	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.7532
p.G30V	DO7938	COAD	ICGC	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.7532
p.E38K	TCGA-CQ-5331	HNSC	TCGA	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.1389
p.E38K	DO15495	HNSC	ICGC	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.1389
p.I22V	TCGA-LN-A49O	ESCA	TCGA	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.2222
p.I22V	TCGA-R6-A6Y0	ESCA	TCGA	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.2222
p.E20K	DO48388	BLCA	ICGC	NESSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons