DegronMD

Uniprot ID: Q9NXF7

Source protein: DDB1- and CUL4-associated factor 16

Source gene: DCAF16

Class: DEG_Kelch_Keap1_1

Location: 26:31

E3 ligase: KEAP1

DEGRON score: 0.8542

ASA_SCORE: 86.2833

COIL: 0.7218

CONS_SCORE: 0.9539

DSS_SCORE: 0.7196

HELIX: 0.233

FCONS_SCORE: 1.0531

RIG_SCORE: 0.5879

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S29Y	TCGA-AJ-A3EK	UCEC	TCGA	NESSGE	DEG_Kelch_Keap1_1	0.712
p.S29Y	TCGA-AX-A2HC	UCEC	TCGA	NESSGE	DEG_Kelch_Keap1_1	0.712
p.S29Y	DO41584	UCEC	ICGC	NESSGE	DEG_Kelch_Keap1_1	0.712
p.S29Y	DO41572	UCEC	ICGC	NESSGE	DEG_Kelch_Keap1_1	0.712
p.Y24C	TCGA-BB-4223	HNSC	TCGA	NESSGE	DEG_Kelch_Keap1_1	0.2778
p.Y24C	DO15607	HNSC	ICGC	NESSGE	DEG_Kelch_Keap1_1	0.2778
p.G30V	TCGA-CK-6746	COAD	TCGA	NESSGE	DEG_Kelch_Keap1_1	0.7532
p.G30V	DO7938	COAD	ICGC	NESSGE	DEG_Kelch_Keap1_1	0.7532
p.E38K	TCGA-CQ-5331	HNSC	TCGA	NESSGE	DEG_Kelch_Keap1_1	0.1389
p.E38K	DO15495	HNSC	ICGC	NESSGE	DEG_Kelch_Keap1_1	0.1389
p.I22V	TCGA-LN-A49O	ESCA	TCGA	NESSGE	DEG_Kelch_Keap1_1	0.2222
p.I22V	TCGA-R6-A6Y0	ESCA	TCGA	NESSGE	DEG_Kelch_Keap1_1	0.2222
p.E20K	DO48388	BLCA	ICGC	NESSGE	DEG_Kelch_Keap1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXF7	DDB1- and CUL4-associated factor 16	DEG_Kelch_Keap1_1	26:31	NESSGE	KEAP1	0.8542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons