DegronMD - Q9NXG2(THUMPD1)

GO - Biological processes (BP): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K152T	TCGA-A5-A0G2	UCEC	TCGA	TRVILRMLP	DEG_APCC_DBOX_1	156:164	Mutation substituting flanking lysine	0.3333
p.K152T	DO41235	UCEC	ICGC	TRVILRMLP	DEG_APCC_DBOX_1	156:164	Mutation substituting flanking lysine	0.3333
p.Y149H	TCGA-AA-A00N	COAD	TCGA	TRVILRMLP	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.1389
p.Y149H	DO9876	COAD	ICGC	TRVILRMLP	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.1389
p.R157Q	TCGA-EO-A3B0	UCEC	TCGA	TRVILRMLP	DEG_APCC_DBOX_1	156:164	Mutation altering degron motif	0.7329
p.R157Q	DO219773	UCEC	ICGC	TRVILRMLP	DEG_APCC_DBOX_1	156:164	Mutation altering degron motif	0.7329
p.R161Q	SIDM00500	Colorectal Carcinoma	GDSC	TRVILRMLP	DEG_APCC_DBOX_1	156:164	Mutation altering degron motif	0.6218
p.D147N	ACH-001127	Leukemia	CCLE	TRVILRMLP	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons