DegronMD

Uniprot ID: Q9NXG2

Source protein: THUMP domain-containing protein 1

Source gene: THUMPD1

Class: DEG_APCC_DBOX_1

Location: 156:164

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6529

ASA_SCORE: 38.0222

COIL: 0.2856

CONS_SCORE: 0.6545

DSS_SCORE: 0.1862

HELIX: 0.0127

FCONS_SCORE: 1.4393

RIG_SCORE: 0.8999

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K152T	TCGA-A5-A0G2	UCEC	TCGA	TRVILRMLP	DEG_APCC_DBOX_1	0.3333
p.K152T	DO41235	UCEC	ICGC	TRVILRMLP	DEG_APCC_DBOX_1	0.3333
p.Y149H	TCGA-AA-A00N	COAD	TCGA	TRVILRMLP	DEG_APCC_DBOX_1	0.1389
p.Y149H	DO9876	COAD	ICGC	TRVILRMLP	DEG_APCC_DBOX_1	0.1389
p.R157Q	TCGA-EO-A3B0	UCEC	TCGA	TRVILRMLP	DEG_APCC_DBOX_1	0.7329
p.R157Q	DO219773	UCEC	ICGC	TRVILRMLP	DEG_APCC_DBOX_1	0.7329
p.R161Q	SIDM00500	Colorectal Carcinoma	GDSC	TRVILRMLP	DEG_APCC_DBOX_1	0.6218
p.D147N	ACH-001127	Leukemia	CCLE	TRVILRMLP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXG2	THUMP domain-containing protein 1	DEG_APCC_DBOX_1	156:164	TRVILRMLP	APC,CDC20,FZR1	0.6529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons