DegronMD - Q9NXH8(TOR4A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S106L	DO222414	BTCA	ICGC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.7222
p.S106L	DO222414	BTCA	ICGC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.7222
p.V100E	DO234268	ESAD	ICGC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.6582
p.V100E	DO234268	ESAD	ICGC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation altering degron motif	0.6582
p.T105A	DO233766	GACA	ICGC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	DO233766	GACA	ICGC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00157	Neuroblastoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00157	Neuroblastoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00592	Oral Cavity Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00592	Oral Cavity Carcinoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00498	Colorectal Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00498	Colorectal Carcinoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00612	Glioma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00612	Glioma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM01653	Non-Cancerous	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM01653	Non-Cancerous	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00397	Acute Myeloid Leukemia	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00397	Acute Myeloid Leukemia	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM01735	Biliary Tract Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM01735	Biliary Tract Carcinoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM01336	Glioblastoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM01336	Glioblastoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM01321	Pancreatic Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM01321	Pancreatic Carcinoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	KINGS-1	central nervous system	COSMIC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	KINGS-1	central nervous system	COSMIC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	HO-1-N-1	salivary gland	COSMIC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	HO-1-N-1	salivary gland	COSMIC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	EC-GI-10	oesophagus	COSMIC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	EC-GI-10	oesophagus	COSMIC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.T105A	KP-N-YS	autonomic ganglia	COSMIC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation blocking phosphorylation signal	0.75
p.T105A	KP-N-YS	autonomic ganglia	COSMIC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.75
p.E114Q	DO14566	HNSC	ICGC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.0556
p.E114Q	DO14566	HNSC	ICGC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.0556
p.P103Q	DO50674	ORCA	ICGC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.5924
p.P103Q	DO50674	ORCA	ICGC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation altering degron motif	0.5924
p.R91H	DO33084	PACA	ICGC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1111
p.R91H	DO33084	PACA	ICGC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.1389
p.R98L	DO51486	PACA	ICGC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation altering degron motif	0.8428
p.R112H	SIDM02021	Esophageal Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1111
p.R112H	SIDM02021	Esophageal Carcinoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.1111
p.R112H	SIDM00596	Endometrial Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1111
p.R112H	SIDM00596	Endometrial Carcinoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.1111
p.R112H	ACH-001517	Endometrial/Uterine Cancer	CCLE	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1111
p.R112H	ACH-001517	Endometrial/Uterine Cancer	CCLE	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.1111
p.R112H	HEC-1	endometrium	COSMIC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1111
p.R112H	HEC-1	endometrium	COSMIC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.1111
p.R110Q	SIDM00596	Endometrial Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1667
p.R110Q	SIDM00596	Endometrial Carcinoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.1667
p.R110Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1667
p.R110Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.1667
p.R110Q	HEC-1	endometrium	COSMIC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1667
p.R110Q	HEC-1	endometrium	COSMIC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.1667
p.V100A	SIDM00217	Colorectal Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.5825
p.V100A	SIDM00217	Colorectal Carcinoma	GDSC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation altering degron motif	0.5825
p.V100A	ACH-000999	Colon/Colorectal Cancer	CCLE	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.5825
p.V100A	ACH-000999	Colon/Colorectal Cancer	CCLE	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation altering degron motif	0.5825
p.V100A	SNU-1040	large intestine	COSMIC	LVLYPE	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.5825
p.V100A	SNU-1040	large intestine	COSMIC	RLVLYPE	LIG_APCC_ABBAyCdc20_2	98:104	Mutation altering degron motif	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOR4A

UniProt ID: Q9NXH8

Entrez ID: 54863

Protein name: Torsin-4A (Torsin family 4 member A)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TOR4A in