DegronMD

Uniprot ID: Q9NXH8

Source protein: Torsin-4A

Source gene: TOR4A

Class: LIG_APCC_ABBA_1

Location: 99:104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9914

ASA_SCORE: 96.8667

COIL: 0.7782

CONS_SCORE: 0.5656

DSS_SCORE: 0.4862

HELIX: 0.0735

FCONS_SCORE: 1.0652

RIG_SCORE: 0.751

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S106L	DO222414	BTCA	ICGC	LVLYPE	LIG_APCC_ABBA_1	0.7222
p.V100E	DO234268	ESAD	ICGC	LVLYPE	LIG_APCC_ABBA_1	0.6582
p.T105A	DO233766	GACA	ICGC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM00157	Neuroblastoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM00592	Oral Cavity Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM00498	Colorectal Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM00612	Glioma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM01653	Non-Cancerous	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM00397	Acute Myeloid Leukemia	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM01735	Biliary Tract Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM01336	Glioblastoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM01321	Pancreatic Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	KINGS-1	central_nervous_system	COSMIC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	HO-1-N-1	salivary_gland	COSMIC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	EC-GI-10	oesophagus	COSMIC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.T105A	KP-N-YS	autonomic_ganglia	COSMIC	LVLYPE	LIG_APCC_ABBA_1	0.75
p.E114Q	DO14566	HNSC	ICGC	LVLYPE	LIG_APCC_ABBA_1	0.0556
p.P103Q	DO50674	ORCA	ICGC	LVLYPE	LIG_APCC_ABBA_1	0.5924
p.R91H	DO33084	PACA	ICGC	LVLYPE	LIG_APCC_ABBA_1	0.1111
p.R112H	SIDM02021	Esophageal Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.1111
p.R112H	SIDM00596	Endometrial Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.1111
p.R112H	ACH-001517	Endometrial/Uterine Cancer	CCLE	LVLYPE	LIG_APCC_ABBA_1	0.1111
p.R112H	HEC-1	endometrium	COSMIC	LVLYPE	LIG_APCC_ABBA_1	0.1111
p.R110Q	SIDM00596	Endometrial Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.1667
p.R110Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	LVLYPE	LIG_APCC_ABBA_1	0.1667
p.R110Q	HEC-1	endometrium	COSMIC	LVLYPE	LIG_APCC_ABBA_1	0.1667
p.V100A	SIDM00217	Colorectal Carcinoma	GDSC	LVLYPE	LIG_APCC_ABBA_1	0.5825
p.V100A	ACH-000999	Colon/Colorectal Cancer	CCLE	LVLYPE	LIG_APCC_ABBA_1	0.5825
p.V100A	SNU-1040	large_intestine	COSMIC	LVLYPE	LIG_APCC_ABBA_1	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LVLYPE

Degron related mutations and impact score

Drug responses associated with TOR4A mutations

All proteins holding degron of LVLYPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXH8	Torsin-4A	LIG_APCC_ABBA_1	99:104	LVLYPE	APC,CDC20,FZR1	0.9914	More...