DegronMD - Q9NXJ0(MS4A12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N260Y	TCGA-20-0996	OV	TCGA	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.1111
p.N260Y	TCGA-20-0996	OV	TCGA	PASSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.S244R	TCGA-73-4659	LUAD	TCGA	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation blocking phosphorylation signal	0.7222
p.S244R	TCGA-73-4659	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	249:253	Mutation blocking phosphorylation signal	0.6389
p.P255H	TCGA-AA-A010	COAD	TCGA	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.25
p.P255H	TCGA-AA-A010	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.A250P	TCGA-BC-A8YO	LIHC	TCGA	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation altering degron motif	0.6392
p.A250P	TCGA-BC-A8YO	LIHC	TCGA	PASSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6392
p.A250P	DO49658	LIHC	ICGC	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation altering degron motif	0.6392
p.A250P	DO49658	LIHC	ICGC	PASSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6392
p.S252Y	TCGA-D1-A17Q	UCEC	TCGA	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation altering degron motif	0.712
p.S252Y	TCGA-D1-A17Q	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.712
p.A250V	TCGA-D5-6538	COAD	TCGA	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation altering degron motif	0.5825
p.A250V	TCGA-D5-6538	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.5825
p.M241I	DO228971	LICA	ICGC	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.1944
p.M241I	DO228971	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1111
p.A263V	SIDM00652	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.A263V	ACH-000780	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.A263V	NCI-H1105	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.N260I	SIDM00735	Small Cell Lung Carcinoma	GDSC	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.1111
p.N260I	SIDM00735	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.N260I	ACH-000298	Lung Cancer	CCLE	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.1111
p.N260I	ACH-000298	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.N260I	NCI-H2029	lung	COSMIC	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation rewiring degron network	0.1111
p.N260I	NCI-H2029	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.S251F	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation altering degron motif	0.6871
p.S251F	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7982
p.S251F	ACH-002222	Leukemia	CCLE	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation altering degron motif	0.6871
p.S251F	ACH-002222	Leukemia	CCLE	PASSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7982
p.S251F	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PVTPASS	DEG_SCF_FBW7_1	246:252	Mutation altering degron motif	0.6871
p.S251F	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MS4A12

UniProt ID: Q9NXJ0

Entrez ID: 54860

Protein name: Membrane-spanning 4-domains subfamily A member 12

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MS4A12 in