DegronMD

Uniprot ID: Q9NXJ0

Source protein: Membrane-spanning 4-domains subfamily A member 12

Source gene: MS4A12

Class: DEG_SCF_FBW7_1

Location: 246:252

E3 ligase: FBXW7

DEGRON score: 0.8889

ASA_SCORE: 84.3714

COIL: 0.9544

CONS_SCORE: 0.3127

DSS_SCORE: 0.4891

HELIX: 0.018

FCONS_SCORE: 0.9027

RIG_SCORE: 0.6399

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N260Y	TCGA-20-0996	OV	TCGA	PVTPASS	DEG_SCF_FBW7_1	0.1111
p.S244R	TCGA-73-4659	LUAD	TCGA	PVTPASS	DEG_SCF_FBW7_1	0.7222
p.P255H	TCGA-AA-A010	COAD	TCGA	PVTPASS	DEG_SCF_FBW7_1	0.25
p.A250P	TCGA-BC-A8YO	LIHC	TCGA	PVTPASS	DEG_SCF_FBW7_1	0.6392
p.A250P	DO49658	LIHC	ICGC	PVTPASS	DEG_SCF_FBW7_1	0.6392
p.S252Y	TCGA-D1-A17Q	UCEC	TCGA	PVTPASS	DEG_SCF_FBW7_1	0.712
p.A250V	TCGA-D5-6538	COAD	TCGA	PVTPASS	DEG_SCF_FBW7_1	0.5825
p.M241I	DO228971	LICA	ICGC	PVTPASS	DEG_SCF_FBW7_1	0.1944
p.N260I	SIDM00735	Small Cell Lung Carcinoma	GDSC	PVTPASS	DEG_SCF_FBW7_1	0.1111
p.N260I	ACH-000298	Lung Cancer	CCLE	PVTPASS	DEG_SCF_FBW7_1	0.1111
p.N260I	NCI-H2029	lung	COSMIC	PVTPASS	DEG_SCF_FBW7_1	0.1111
p.S251F	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PVTPASS	DEG_SCF_FBW7_1	0.6871
p.S251F	ACH-002222	Leukemia	CCLE	PVTPASS	DEG_SCF_FBW7_1	0.6871
p.S251F	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PVTPASS	DEG_SCF_FBW7_1	0.6871

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXJ0	Membrane-spanning 4-domains subfamily A member 12	DEG_SCF_FBW7_1	246:252	PVTPASS	FBXW7	0.8889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons