DegronMD - Q9NXW2(DNAJB12)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R360W	TCGA-AA-3715	COAD	TCGA	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation altering degron motif	0.8634
p.R360W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation altering degron motif	0.8634
p.R360W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation altering degron motif	0.8634
p.E348Q	TCGA-E2-A574	BRCA	TCGA	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation rewiring degron network	0.0556
p.R349W	TCGA-E6-A1LX	UCEC	TCGA	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation rewiring degron network	0.0833
p.E352D	TCGA-FI-A2D5	UCEC	TCGA	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation blocking phosphorylation signal	0.6111
p.K370N	TCGA-FS-A1ZN	SKCM	TCGA	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation rewiring degron network	0.1667
p.R360Q	TCGA-G4-6586	COAD	TCGA	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation altering degron motif	0.7329
p.A357T	TCGA-WS-AB45	COAD	TCGA	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation rewiring degron network	0.3056
p.D353E	SIDM01165	Pancreatic Carcinoma	GDSC	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation rewiring degron network	0.1944
p.D353E	SW1990	pancreas	COSMIC	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation rewiring degron network	0.1944
p.I356V	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation rewiring degron network	0.2778
p.I356V	TE-4	oesophagus	COSMIC	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation rewiring degron network	0.2778
p.G359D	ACH-001520	Leukemia	CCLE	MGTPSCS	DEG_SCF_FBW7_1	358:364	Mutation altering degron motif	0.6087

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons