DegronMD

Uniprot ID: Q9NXW2

Source protein: DnaJ homolog subfamily B member 12

Source gene: DNAJB12

Class: DEG_SCF_FBW7_1

Location: 358:364

E3 ligase: FBXW7

DEGRON score: 0.9725

ASA_SCORE: 52.9429

COIL: 0.7307

CONS_SCORE: 0.4527

DSS_SCORE: 0.4571

HELIX: 0.263

FCONS_SCORE: 1.4306

RIG_SCORE: 0.6959

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R360W	TCGA-AA-3715	COAD	TCGA	MGTPSCS	DEG_SCF_FBW7_1	0.8634
p.R360W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MGTPSCS	DEG_SCF_FBW7_1	0.8634
p.R360W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	MGTPSCS	DEG_SCF_FBW7_1	0.8634
p.E348Q	TCGA-E2-A574	BRCA	TCGA	MGTPSCS	DEG_SCF_FBW7_1	0.0556
p.R349W	TCGA-E6-A1LX	UCEC	TCGA	MGTPSCS	DEG_SCF_FBW7_1	0.0833
p.E352D	TCGA-FI-A2D5	UCEC	TCGA	MGTPSCS	DEG_SCF_FBW7_1	0.6111
p.K370N	TCGA-FS-A1ZN	SKCM	TCGA	MGTPSCS	DEG_SCF_FBW7_1	0.1667
p.R360Q	TCGA-G4-6586	COAD	TCGA	MGTPSCS	DEG_SCF_FBW7_1	0.7329
p.A357T	TCGA-WS-AB45	COAD	TCGA	MGTPSCS	DEG_SCF_FBW7_1	0.3056
p.D353E	SIDM01165	Pancreatic Carcinoma	GDSC	MGTPSCS	DEG_SCF_FBW7_1	0.1944
p.D353E	SW1990	pancreas	COSMIC	MGTPSCS	DEG_SCF_FBW7_1	0.1944
p.I356V	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	MGTPSCS	DEG_SCF_FBW7_1	0.2778
p.I356V	TE-4	oesophagus	COSMIC	MGTPSCS	DEG_SCF_FBW7_1	0.2778
p.G359D	ACH-001520	Leukemia	CCLE	MGTPSCS	DEG_SCF_FBW7_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXW2	DnaJ homolog subfamily B member 12	DEG_SCF_FBW7_1	358:364	MGTPSCS	FBXW7	0.9725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons