DegronMD - Q9NY33(DPP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G482C	TCGA-55-8506	LUAD	TCGA	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation altering degron motif	0.76
p.Q484H	TCGA-A5-A1OF	UCEC	TCGA	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation rewiring degron network	0.3056
p.A468V	TCGA-B0-5098	KIRC	TCGA	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation rewiring degron network	0.0556
p.G492E	TCGA-B5-A3FA	UCEC	TCGA	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation rewiring degron network	0.0833
p.D472N	TCGA-BL-A3JM	BLCA	TCGA	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation rewiring degron network	0.1667
p.E493Q	TCGA-CV-7091	HNSC	TCGA	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation rewiring degron network	0.0556
p.P479S	TCGA-D3-A8GI	SKCM	TCGA	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation altering degron motif	0.5641
p.R490W	TCGA-EO-A22U	UCEC	TCGA	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation rewiring degron network	0.1389
p.A488V	DO18938	KIRC	ICGC	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation rewiring degron network	0.1944
p.G478C	DO228978	LICA	ICGC	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation altering degron motif	0.76
p.G476C	DO229037	LICA	ICGC	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation rewiring degron network	0.2778
p.G477V	DO26490	LUSC	ICGC	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation rewiring degron network	0.3056
p.G477D	Jurkat	haematopoietic and lymphoid tissue	COSMIC	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation rewiring degron network	0.3056
p.G478D	Jurkat	haematopoietic and lymphoid tissue	COSMIC	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation altering degron motif	0.7198
p.E482K	J82	urinary tract	COSMIC	NPETGE	DEG_Kelch_Keap1_1	478:483	Mutation altering degron motif	0.7022

Kaplan plot for DPP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DPP3

UniProt ID: Q9NY33

Entrez ID: 10072

Protein name: Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DPP3 in