DegronMD

Uniprot ID: Q9NY33

Source protein: Dipeptidyl peptidase 3

Source gene: DPP3

Class: DEG_Kelch_Keap1_1

Location: 478:483

E3 ligase: KEAP1

DEGRON score: 0.5015

ASA_SCORE: 69.8667

COIL: 0.866

CONS_SCORE: 0.5157

DSS_SCORE: 0.4555

HELIX: 0.0668

FCONS_SCORE: 1.0896

RIG_SCORE: 0.79

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G482C	TCGA-55-8506	LUAD	TCGA	NPETGE	DEG_Kelch_Keap1_1	0.76
p.Q484H	TCGA-A5-A1OF	UCEC	TCGA	NPETGE	DEG_Kelch_Keap1_1	0.3056
p.A468V	TCGA-B0-5098	KIRC	TCGA	NPETGE	DEG_Kelch_Keap1_1	0.0556
p.G492E	TCGA-B5-A3FA	UCEC	TCGA	NPETGE	DEG_Kelch_Keap1_1	0.0833
p.D472N	TCGA-BL-A3JM	BLCA	TCGA	NPETGE	DEG_Kelch_Keap1_1	0.1667
p.E493Q	TCGA-CV-7091	HNSC	TCGA	NPETGE	DEG_Kelch_Keap1_1	0.0556
p.P479S	TCGA-D3-A8GI	SKCM	TCGA	NPETGE	DEG_Kelch_Keap1_1	0.5641
p.R490W	TCGA-EO-A22U	UCEC	TCGA	NPETGE	DEG_Kelch_Keap1_1	0.1389
p.A488V	DO18938	KIRC	ICGC	NPETGE	DEG_Kelch_Keap1_1	0.1944
p.G478C	DO228978	LICA	ICGC	NPETGE	DEG_Kelch_Keap1_1	0.76
p.G476C	DO229037	LICA	ICGC	NPETGE	DEG_Kelch_Keap1_1	0.2778
p.G477V	DO26490	LUSC	ICGC	NPETGE	DEG_Kelch_Keap1_1	0.3056
p.G477D	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	NPETGE	DEG_Kelch_Keap1_1	0.3056
p.G478D	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	NPETGE	DEG_Kelch_Keap1_1	0.7198
p.E482K	J82	urinary_tract	COSMIC	NPETGE	DEG_Kelch_Keap1_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NY33	Dipeptidyl peptidase 3	DEG_Kelch_Keap1_1	478:483	NPETGE	KEAP1	0.5015	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons