DegronMD - Q9NYJ7(DLL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q522L	TCGA-14-0866	GBM	TCGA	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation rewiring degron network	0.1389
p.Q522L	DO11878	GBM	ICGC	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation rewiring degron network	0.1389
p.A539S	DO229035	LICA	ICGC	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation rewiring degron network	0.25
p.R527C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation rewiring degron network	0.2778
p.R527C	ACH-000790	Lung Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation rewiring degron network	0.2778
p.R527C	DND-41	haematopoietic and lymphoid tissue	COSMIC	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation rewiring degron network	0.2778
p.D542E	SIDM00541	Colorectal Carcinoma	GDSC	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation rewiring degron network	0.1667
p.D542E	ACH-000926	Colon/Colorectal Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation rewiring degron network	0.1667
p.S521F	SIDM00620	Glioblastoma	GDSC	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation blocking phosphorylation signal	0.5556
p.S521F	SIDM00025	Head and Neck Carcinoma	GDSC	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation blocking phosphorylation signal	0.5556
p.P533L	ACH-000790	Lung Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation altering degron motif	0.7582
p.S536L	ACH-000790	Lung Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation altering degron motif	0.7667
p.R527P	ACH-000945	Lung Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation rewiring degron network	0.2778
p.L528S	ACH-000958	Colon/Colorectal Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation rewiring degron network	0.3056
p.G519D	ACH-000961	Endometrial/Uterine Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	529:536	Mutation rewiring degron network	0.0556

Kaplan plot for DLL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLL3

UniProt ID: Q9NYJ7

Entrez ID: 10683

Protein name: Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLL3 in