DegronMD

Uniprot ID: Q9NYJ7

Source protein: Delta-like protein 3

Source gene: DLL3

Class: DEG_SCF_FBW7_1

Location: 529:536

E3 ligase: FBXW7

DEGRON score: 0.8988

ASA_SCORE: 52.375

COIL: 0.5975

CONS_SCORE: 0.9073

DSS_SCORE: 0.568

HELIX: 0.0391

FCONS_SCORE: 1.0524

RIG_SCORE: 0.6321

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q522L	TCGA-14-0866	GBM	TCGA	LAGTPEPS	DEG_SCF_FBW7_1	0.1389
p.Q522L	DO11878	GBM	ICGC	LAGTPEPS	DEG_SCF_FBW7_1	0.1389
p.A539S	DO229035	LICA	ICGC	LAGTPEPS	DEG_SCF_FBW7_1	0.25
p.R527C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAGTPEPS	DEG_SCF_FBW7_1	0.2778
p.R527C	ACH-000790	Lung Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	0.2778
p.R527C	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LAGTPEPS	DEG_SCF_FBW7_1	0.2778
p.D542E	SIDM00541	Colorectal Carcinoma	GDSC	LAGTPEPS	DEG_SCF_FBW7_1	0.1667
p.D542E	ACH-000926	Colon/Colorectal Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	0.1667
p.S521F	SIDM00620	Glioblastoma	GDSC	LAGTPEPS	DEG_SCF_FBW7_1	0.5556
p.S521F	SIDM00025	Head and Neck Carcinoma	GDSC	LAGTPEPS	DEG_SCF_FBW7_1	0.5556
p.P533L	ACH-000790	Lung Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	0.7582
p.S536L	ACH-000790	Lung Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	0.7667
p.R527P	ACH-000945	Lung Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	0.2778
p.L528S	ACH-000958	Colon/Colorectal Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	0.3056
p.G519D	ACH-000961	Endometrial/Uterine Cancer	CCLE	LAGTPEPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYJ7	Delta-like protein 3	DEG_SCF_FBW7_1	529:536	LAGTPEPS	FBXW7	0.8988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons