DegronMD - Q9NYK5(MRPL39)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G71W	TCGA-09-2044	OV	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation rewiring degron network	0.1111
p.G71W	DO28923	OV	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation rewiring degron network	0.1111
p.A53G	TCGA-85-8355	LUSC	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation rewiring degron network	0.25
p.A53G	DO45488	LUSC	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation rewiring degron network	0.25
p.R61Q	TCGA-AP-A056	UCEC	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.6218
p.R61Q	TCGA-BK-A6W3	UCEC	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.6218
p.R61Q	TCGA-EO-A3AV	UCEC	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.6218
p.R61Q	DO50076	UCEC	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.6218
p.R61Q	DO52412	UCEC	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.6218
p.R61Q	DO43971	UCEC	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.6218
p.R61Q	SIDM01611	Endometrial Carcinoma	GDSC	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.6218
p.R61Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.6218
p.R61G	TCGA-BA-7269	HNSC	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.6457
p.R61G	DO14166	HNSC	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.6457
p.T59P	TCGA-DK-A6AW	BLCA	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.8142
p.T59P	DO48566	BLCA	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.8142
p.T59N	DO233722	GACA	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation altering degron motif	0.8166
p.Q55K	DO229041	LICA	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation rewiring degron network	0.3056
p.L47F	SIDM01611	Endometrial Carcinoma	GDSC	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation rewiring degron network	0.0833
p.L47F	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSLTPRTE	DEG_SCF_FBW7_2	56:63	Mutation rewiring degron network	0.0833

Kaplan plot for MRPL39 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MRPL39

UniProt ID: Q9NYK5

Entrez ID: 54148

Protein name: 39S ribosomal protein L39, mitochondrial (L39mt) (MRP-L39) (39S ribosomal protein L5, mitochondrial) (L5mt) (MRP-L5) (Mitochondrial large ribosomal subunit protein mL39)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MRPL39 in