DegronMD

Uniprot ID: Q9NYK5

Source protein: 39S ribosomal protein L39, mitochondrial

Source gene: MRPL39

Class: DEG_SCF_FBW7_2

Location: 56:63

E3 ligase: FBXW7

DEGRON score: 0.9395

ASA_SCORE: 86.5125

COIL: 0.7863

CONS_SCORE: 0.5817

DSS_SCORE: 0.4598

HELIX: 0.1611

FCONS_SCORE: 1.0393

RIG_SCORE: 0.7337

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T59N	DO233722	GACA	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	0.8166
p.T59P	TCGA-DK-A6AW	BLCA	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	0.8142
p.T59P	DO48566	BLCA	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	0.8142
p.R61G	TCGA-BA-7269	HNSC	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	0.6457
p.R61G	DO14166	HNSC	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	0.6457
p.R61Q	TCGA-AP-A056	UCEC	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	0.6218
p.R61Q	TCGA-BK-A6W3	UCEC	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	0.6218
p.R61Q	TCGA-EO-A3AV	UCEC	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	0.6218
p.R61Q	DO50076	UCEC	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	0.6218
p.R61Q	DO52412	UCEC	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	0.6218
p.R61Q	DO43971	UCEC	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	0.6218
p.R61Q	SIDM01611	Endometrial Carcinoma	GDSC	LSLTPRTE	DEG_SCF_FBW7_2	0.6218
p.R61Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSLTPRTE	DEG_SCF_FBW7_2	0.6218
p.Q55K	DO229041	LICA	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	0.3056
p.A53G	TCGA-85-8355	LUSC	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	0.25
p.A53G	DO45488	LUSC	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	0.25
p.G71W	TCGA-09-2044	OV	TCGA	LSLTPRTE	DEG_SCF_FBW7_2	0.1111
p.G71W	DO28923	OV	ICGC	LSLTPRTE	DEG_SCF_FBW7_2	0.1111
p.L47F	SIDM01611	Endometrial Carcinoma	GDSC	LSLTPRTE	DEG_SCF_FBW7_2	0.0833
p.L47F	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSLTPRTE	DEG_SCF_FBW7_2	0.0833

Showing 1 to 20 of 20 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYK5	39S ribosomal protein L39, mitochondrial	DEG_SCF_FBW7_2	56:63	LSLTPRTE	FBXW7	0.9395	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons