DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LSLTPRTE
Uniprot ID:
Q9NYK5
Source protein:
39S ribosomal protein L39, mitochondrial
Source gene:
MRPL39
Class:
DEG_SCF_FBW7_2
Location:
56:63
E3 ligase:
FBXW7
DEGRON score:
0.9395
ASA_SCORE:
86.5125
COIL:
0.7863
CONS_SCORE:
0.5817
DSS_SCORE:
0.4598
HELIX:
0.1611
FCONS_SCORE:
1.0393
RIG_SCORE:
0.7337
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G71W
TCGA-09-2044
OV
TCGA
LSLTPRTE
DEG_SCF_FBW7_2
0.1111
p.G71W
DO28923
OV
ICGC
LSLTPRTE
DEG_SCF_FBW7_2
0.1111
p.A53G
TCGA-85-8355
LUSC
TCGA
LSLTPRTE
DEG_SCF_FBW7_2
0.25
p.A53G
DO45488
LUSC
ICGC
LSLTPRTE
DEG_SCF_FBW7_2
0.25
p.R61Q
TCGA-AP-A056
UCEC
TCGA
LSLTPRTE
DEG_SCF_FBW7_2
0.6218
p.R61Q
TCGA-BK-A6W3
UCEC
TCGA
LSLTPRTE
DEG_SCF_FBW7_2
0.6218
p.R61Q
TCGA-EO-A3AV
UCEC
TCGA
LSLTPRTE
DEG_SCF_FBW7_2
0.6218
p.R61Q
DO50076
UCEC
ICGC
LSLTPRTE
DEG_SCF_FBW7_2
0.6218
p.R61Q
DO52412
UCEC
ICGC
LSLTPRTE
DEG_SCF_FBW7_2
0.6218
p.R61Q
DO43971
UCEC
ICGC
LSLTPRTE
DEG_SCF_FBW7_2
0.6218
p.R61Q
SIDM01611
Endometrial Carcinoma
GDSC
LSLTPRTE
DEG_SCF_FBW7_2
0.6218
p.R61Q
ACH-000996
Endometrial/Uterine Cancer
CCLE
LSLTPRTE
DEG_SCF_FBW7_2
0.6218
p.R61G
TCGA-BA-7269
HNSC
TCGA
LSLTPRTE
DEG_SCF_FBW7_2
0.6457
p.R61G
DO14166
HNSC
ICGC
LSLTPRTE
DEG_SCF_FBW7_2
0.6457
p.T59P
TCGA-DK-A6AW
BLCA
TCGA
LSLTPRTE
DEG_SCF_FBW7_2
0.8142
p.T59P
DO48566
BLCA
ICGC
LSLTPRTE
DEG_SCF_FBW7_2
0.8142
p.T59N
DO233722
GACA
ICGC
LSLTPRTE
DEG_SCF_FBW7_2
0.8166
p.Q55K
DO229041
LICA
ICGC
LSLTPRTE
DEG_SCF_FBW7_2
0.3056
p.L47F
SIDM01611
Endometrial Carcinoma
GDSC
LSLTPRTE
DEG_SCF_FBW7_2
0.0833
p.L47F
ACH-000996
Endometrial/Uterine Cancer
CCLE
LSLTPRTE
DEG_SCF_FBW7_2
0.0833
Drug responses associated with MRPL39 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LSLTPRTE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NYK5
39S ribosomal protein L39, mitochondrial
DEG_SCF_FBW7_2
56:63
LSLTPRTE
FBXW7
0.9395
More...