DegronMD - Q9NYL9(TMOD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V176I	TCGA-CI-6622	READ	TCGA	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation altering degron motif	0.5965
p.V176I	DO36435	READ	ICGC	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation altering degron motif	0.5965
p.E187Q	TCGA-DK-A6B6	BLCA	TCGA	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.1111
p.E187Q	DO48576	BLCA	ICGC	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.1111
p.F164L	TCGA-DU-6392	LGG	TCGA	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.0556
p.F164L	DO22237	LGG	ICGC	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.0556
p.V186E	DO228976	LICA	ICGC	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.1389
p.S189I	DO229006	LICA	ICGC	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.0556
p.P175S	DO220886	MELA	ICGC	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation altering degron motif	0.5641
p.D178V	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation altering degron motif	0.6674
p.D178V	ACH-000627	Lung Cancer	CCLE	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation altering degron motif	0.6674
p.D178V	LCLC-103H	lung	COSMIC	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation altering degron motif	0.6674
p.T184A	ACH-000044	Breast Cancer	CCLE	LPVFDE	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons