DegronMD

Uniprot ID: Q9NYL9

Source protein: Tropomodulin-3

Source gene: TMOD3

Class: LIG_APCC_ABBA_1

Location: 174:179

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.975

ASA_SCORE: 49.0167

COIL: 0.7227

CONS_SCORE: 0.6942

DSS_SCORE: 0.5223

HELIX: 0.0438

FCONS_SCORE: 0.9582

RIG_SCORE: 0.7621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V176I	TCGA-CI-6622	READ	TCGA	LPVFDE	LIG_APCC_ABBA_1	0.5965
p.V176I	DO36435	READ	ICGC	LPVFDE	LIG_APCC_ABBA_1	0.5965
p.E187Q	TCGA-DK-A6B6	BLCA	TCGA	LPVFDE	LIG_APCC_ABBA_1	0.1111
p.E187Q	DO48576	BLCA	ICGC	LPVFDE	LIG_APCC_ABBA_1	0.1111
p.F164L	TCGA-DU-6392	LGG	TCGA	LPVFDE	LIG_APCC_ABBA_1	0.0556
p.F164L	DO22237	LGG	ICGC	LPVFDE	LIG_APCC_ABBA_1	0.0556
p.V186E	DO228976	LICA	ICGC	LPVFDE	LIG_APCC_ABBA_1	0.1389
p.S189I	DO229006	LICA	ICGC	LPVFDE	LIG_APCC_ABBA_1	0.0556
p.P175S	DO220886	MELA	ICGC	LPVFDE	LIG_APCC_ABBA_1	0.5641
p.D178V	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	LPVFDE	LIG_APCC_ABBA_1	0.6674
p.D178V	ACH-000627	Lung Cancer	CCLE	LPVFDE	LIG_APCC_ABBA_1	0.6674
p.D178V	LCLC-103H	lung	COSMIC	LPVFDE	LIG_APCC_ABBA_1	0.6674
p.T184A	ACH-000044	Breast Cancer	CCLE	LPVFDE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYL9	Tropomodulin-3	LIG_APCC_ABBA_1	174:179	LPVFDE	APC,CDC20,FZR1	0.975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons