DegronMD - Q9NYT6(ZNF226)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V13M	TCGA-19-1787	GBM	TCGA	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1389
p.V13M	DO13522	GBM	ICGC	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1389
p.A16T	TCGA-AP-A1DV	UCEC	TCGA	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556
p.A16T	DO43186	UCEC	ICGC	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556
p.F4L	TCGA-CN-6010	HNSC	TCGA	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.6981
p.F4L	DO14766	HNSC	ICGC	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.6981
p.A14S	TCGA-DD-A4NK	LIHC	TCGA	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1111
p.A14S	DO44882	LIHC	ICGC	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1111
p.A7S	DO229031	LICA	ICGC	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.3056
p.A7S	DO232013	ORCA	ICGC	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.3056
p.V8L	DO229037	LICA	ICGC	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.2778
p.V8A	SIDM01045	Endometrial Carcinoma	GDSC	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.2778
p.V8A	ACH-000978	Endometrial/Uterine Cancer	CCLE	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.2778
p.V8A	EN	endometrium	COSMIC	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.2778
p.N2S	SIDM00011	Melanoma	GDSC	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.5958
p.N2S	ACH-000477	Skin Cancer	CCLE	MNMFKE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.5958

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons