DegronMD

Uniprot ID: Q9NYT6

Source protein: Zinc finger protein 226

Source gene: ZNF226

Class: LIG_APCC_ABBA_1

Location: 1:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9831

ASA_SCORE: 126.0667

COIL: 0.9652

CONS_SCORE: 0.4709

DSS_SCORE: 0.5367

HELIX: 0.0147

FCONS_SCORE: 0.7655

RIG_SCORE: 0.8202

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V13M	TCGA-19-1787	GBM	TCGA	MNMFKE	LIG_APCC_ABBA_1	0.1389
p.V13M	DO13522	GBM	ICGC	MNMFKE	LIG_APCC_ABBA_1	0.1389
p.A16T	TCGA-AP-A1DV	UCEC	TCGA	MNMFKE	LIG_APCC_ABBA_1	0.0556
p.A16T	DO43186	UCEC	ICGC	MNMFKE	LIG_APCC_ABBA_1	0.0556
p.F4L	TCGA-CN-6010	HNSC	TCGA	MNMFKE	LIG_APCC_ABBA_1	0.6981
p.F4L	DO14766	HNSC	ICGC	MNMFKE	LIG_APCC_ABBA_1	0.6981
p.A14S	TCGA-DD-A4NK	LIHC	TCGA	MNMFKE	LIG_APCC_ABBA_1	0.1111
p.A14S	DO44882	LIHC	ICGC	MNMFKE	LIG_APCC_ABBA_1	0.1111
p.A7S	DO229031	LICA	ICGC	MNMFKE	LIG_APCC_ABBA_1	0.3056
p.A7S	DO232013	ORCA	ICGC	MNMFKE	LIG_APCC_ABBA_1	0.3056
p.V8L	DO229037	LICA	ICGC	MNMFKE	LIG_APCC_ABBA_1	0.2778
p.V8A	SIDM01045	Endometrial Carcinoma	GDSC	MNMFKE	LIG_APCC_ABBA_1	0.2778
p.V8A	ACH-000978	Endometrial/Uterine Cancer	CCLE	MNMFKE	LIG_APCC_ABBA_1	0.2778
p.V8A	EN	endometrium	COSMIC	MNMFKE	LIG_APCC_ABBA_1	0.2778
p.N2S	SIDM00011	Melanoma	GDSC	MNMFKE	LIG_APCC_ABBA_1	0.5958
p.N2S	ACH-000477	Skin Cancer	CCLE	MNMFKE	LIG_APCC_ABBA_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYT6	Zinc finger protein 226	LIG_APCC_ABBA_1	1:6	MNMFKE	APC,CDC20,FZR1	0.9831	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons