DegronMD - Q9NZ01(TECR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A27T	TCGA-B6-A1KF	BRCA	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1667
p.A27T	TCGA-G4-6628	COAD	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1667
p.A27T	DO1604	BRCA	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1667
p.A27T	DO10132	COAD	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1667
p.A27T	DO41199	UCEC	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1667
p.K12N	TCGA-BS-A0UV	UCEC	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation blocking ubiquitination signal	0.75
p.K12N	DO42793	UCEC	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation blocking ubiquitination signal	0.75
p.Y4H	TCGA-D1-A3DA	UCEC	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation blocking phosphorylation signal	0.5278
p.Y4H	DO43258	UCEC	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation blocking phosphorylation signal	0.5278
p.I29T	TCGA-XF-A9SV	BLCA	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1111
p.I29T	DO219047	BLCA	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1111
p.E5K	TCGA-ZF-AA51	BLCA	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1111
p.C18Y	DO223732	CESC	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.5976
p.E24D	DO228986	LICA	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.25
p.V23M	SIDM00789	Colorectal Carcinoma	GDSC	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778
p.V23M	HCT-15	large intestine	COSMIC	TREKLCFLD	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778

Kaplan plot for TECR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TECR

UniProt ID: Q9NZ01

Entrez ID: 9524

Protein name: Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TECR in