DegronMD

Uniprot ID: Q9NZ01

Source protein: Very-long-chain enoyl-CoA reductase

Source gene: TECR

Class: DEG_APCC_DBOX_1

Location: 13:21

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5442

ASA_SCORE: 67.6444

COIL: 0.4392

CONS_SCORE: 0.3457

DSS_SCORE: 0.1544

HELIX: 0.0844

FCONS_SCORE: 0.8433

RIG_SCORE: 0.8752

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A27T	TCGA-B6-A1KF	BRCA	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	0.1667
p.A27T	TCGA-G4-6628	COAD	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	0.1667
p.A27T	DO1604	BRCA	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	0.1667
p.A27T	DO10132	COAD	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	0.1667
p.A27T	DO41199	UCEC	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	0.1667
p.K12N	TCGA-BS-A0UV	UCEC	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	0.75
p.K12N	DO42793	UCEC	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	0.75
p.Y4H	TCGA-D1-A3DA	UCEC	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	0.5278
p.Y4H	DO43258	UCEC	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	0.5278
p.I29T	TCGA-XF-A9SV	BLCA	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	0.1111
p.I29T	DO219047	BLCA	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	0.1111
p.E5K	TCGA-ZF-AA51	BLCA	TCGA	TREKLCFLD	DEG_APCC_DBOX_1	0.1111
p.C18Y	DO223732	CESC	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	0.5976
p.E24D	DO228986	LICA	ICGC	TREKLCFLD	DEG_APCC_DBOX_1	0.25
p.V23M	SIDM00789	Colorectal Carcinoma	GDSC	TREKLCFLD	DEG_APCC_DBOX_1	0.2778
p.V23M	HCT-15	large_intestine	COSMIC	TREKLCFLD	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ01	Very-long-chain enoyl-CoA reductase	DEG_APCC_DBOX_1	13:21	TREKLCFLD	APC,CDC20,FZR1	0.5442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons