DegronMD - Q9NZC7(WWOX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S296F	TCGA-56-7822	LUSC	TCGA	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.6871
p.S296F	DO26638	LUSC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.6871
p.R310G	TCGA-CI-6624	READ	TCGA	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1111
p.R310G	DO37130	READ	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1111
p.A289V	TCGA-DF-A2KU	UCEC	TCGA	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1944
p.A289V	DO223286	UCEC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1944
p.K284E	TCGA-ER-A197	SKCM	TCGA	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation substituting flanking lysine	0.1667
p.K284E	DO47519	SKCM	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation substituting flanking lysine	0.1667
p.S296C	TCGA-L5-A8NJ	ESCA	TCGA	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.643
p.L298F	DO227987	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.6981
p.R309S	DO222769	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1389
p.V289A	DO229010	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1944
p.V289A	DO229005	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1944
p.V289A	DO228941	LICA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1944
p.V289A	DO229006	LICA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1944
p.V289A	DO231007	LUSC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1944
p.C287W	DO229010	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation blocking phosphorylation signal	0.5833
p.C287W	DO229005	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation blocking phosphorylation signal	0.5833
p.C287W	DO228941	LICA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation blocking phosphorylation signal	0.5833
p.C287W	DO229006	LICA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation blocking phosphorylation signal	0.5833
p.C287W	DO231007	LUSC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation blocking phosphorylation signal	0.5833
p.A292T	DO233160	GACA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.2778
p.R309L	DO16136	KIRC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1389
p.R291S	DO228976	LICA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.25
p.F304L	DO230530	LUSC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.2778
p.R295S	DO231033	LUSC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.7427
p.F302L	DO41020	UCEC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.6981
p.H299Q	DO41999	UCEC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.7582
p.R310H	SIDM01278	Colorectal Carcinoma	GDSC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1111
p.R310H	SIDM00980	Gastric Carcinoma	GDSC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1111
p.R310H	ACH-000948	Gastric Cancer	CCLE	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1111
p.R310H	23132-87	stomach	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1111
p.R310C	SIDM00770	Small Cell Lung Carcinoma	GDSC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1111
p.A289S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1944
p.A289S	ACH-000809	Esophageal Cancer	CCLE	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1944
p.A289S	KYSE-410	oesophagus	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.1944
p.L311F	SIDM00927	Small Cell Lung Carcinoma	GDSC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.0833
p.L311F	ACH-000871	Lung Cancer	CCLE	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.0833
p.L311F	NCI-H510A	lung	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.0833
p.N285K	ACH-000809	Esophageal Cancer	CCLE	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.0833
p.N285K	KYSE-410	oesophagus	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.0833
p.S304F	ACH-001719	Ovarian Cancer	CCLE	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.2778
p.Q301K	Raji	haematopoietic and lymphoid tissue	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation altering degron motif	0.6944
p.F292V	HT	haematopoietic and lymphoid tissue	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.2778
p.K285N	ATN-1	haematopoietic and lymphoid tissue	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation rewiring degron network	0.0833
p.V284L	NCI-H3122	lung	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	294:302	Mutation substituting flanking lysine	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WWOX

UniProt ID: Q9NZC7

Entrez ID: 51741

Protein name: WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WWOX in