DegronMD

Uniprot ID: Q9NZC7

Source protein: WW domain-containing oxidoreductase

Source gene: WWOX

Class: DEG_APCC_DBOX_1

Location: 294:302

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5763

ASA_SCORE: 12.3

COIL: 0.0104

CONS_SCORE: 0.7933

DSS_SCORE: 0.0663

HELIX: 0.9886

FCONS_SCORE: 1.2609

RIG_SCORE: 0.8883

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S296F	TCGA-56-7822	LUSC	TCGA	NRSKLCNIL	DEG_APCC_DBOX_1	0.6871
p.S296F	DO26638	LUSC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.6871
p.R310G	TCGA-CI-6624	READ	TCGA	NRSKLCNIL	DEG_APCC_DBOX_1	0.1111
p.R310G	DO37130	READ	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1111
p.A289V	TCGA-DF-A2KU	UCEC	TCGA	NRSKLCNIL	DEG_APCC_DBOX_1	0.1944
p.A289V	DO223286	UCEC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1944
p.K284E	TCGA-ER-A197	SKCM	TCGA	NRSKLCNIL	DEG_APCC_DBOX_1	0.1667
p.K284E	DO47519	SKCM	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1667
p.S296C	TCGA-L5-A8NJ	ESCA	TCGA	NRSKLCNIL	DEG_APCC_DBOX_1	0.643
p.L298F	DO227987	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.6981
p.R309S	DO222769	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1389
p.V289A	DO229010	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1944
p.V289A	DO229005	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1944
p.V289A	DO228941	LICA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1944
p.V289A	DO229006	LICA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1944
p.V289A	DO231007	LUSC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1944
p.C287W	DO229010	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.5833
p.C287W	DO229005	COCA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.5833
p.C287W	DO228941	LICA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.5833
p.C287W	DO229006	LICA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.5833
p.C287W	DO231007	LUSC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.5833
p.A292T	DO233160	GACA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.2778
p.R309L	DO16136	KIRC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1389
p.R291S	DO228976	LICA	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.25
p.F304L	DO230530	LUSC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.2778
p.R295S	DO231033	LUSC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.7427
p.F302L	DO41020	UCEC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.6981
p.H299Q	DO41999	UCEC	ICGC	NRSKLCNIL	DEG_APCC_DBOX_1	0.7582
p.R310H	SIDM01278	Colorectal Carcinoma	GDSC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1111
p.R310H	SIDM00980	Gastric Carcinoma	GDSC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1111
p.R310H	ACH-000948	Gastric Cancer	CCLE	NRSKLCNIL	DEG_APCC_DBOX_1	0.1111
p.R310H	23132-87	stomach	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1111
p.R310C	SIDM00770	Small Cell Lung Carcinoma	GDSC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1111
p.A289S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1944
p.A289S	ACH-000809	Esophageal Cancer	CCLE	NRSKLCNIL	DEG_APCC_DBOX_1	0.1944
p.A289S	KYSE-410	oesophagus	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1944
p.L311F	SIDM00927	Small Cell Lung Carcinoma	GDSC	NRSKLCNIL	DEG_APCC_DBOX_1	0.0833
p.L311F	ACH-000871	Lung Cancer	CCLE	NRSKLCNIL	DEG_APCC_DBOX_1	0.0833
p.L311F	NCI-H510A	lung	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	0.0833
p.N285K	ACH-000809	Esophageal Cancer	CCLE	NRSKLCNIL	DEG_APCC_DBOX_1	0.0833
p.N285K	KYSE-410	oesophagus	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	0.0833
p.S304F	ACH-001719	Ovarian Cancer	CCLE	NRSKLCNIL	DEG_APCC_DBOX_1	0.2778
p.Q301K	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	0.6944
p.F292V	HT	haematopoietic_and_lymphoid_tissue	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	0.2778
p.K285N	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	0.0833
p.V284L	NCI-H3122	lung	COSMIC	NRSKLCNIL	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRSKLCNIL

Degron related mutations and impact score

Drug responses associated with WWOX mutations

All proteins holding degron of NRSKLCNIL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZC7	WW domain-containing oxidoreductase	DEG_APCC_DBOX_1	294:302	NRSKLCNIL	APC,CDC20,FZR1	0.5763	More...