DegronMD - Q9NZJ5(EIF2AK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P716L	TCGA-D3-A8GM	SKCM	TCGA	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.6471
p.P716L	SIDM00209	Glioblastoma	GDSC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.6471
p.P716L	D-423MG	central nervous system	COSMIC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.6471
p.T705K	TCGA-D7-6528	STAD	TCGA	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation blocking phosphorylation signal	0.5833
p.P714T	TCGA-GD-A76B	BLCA	TCGA	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.7031
p.P714T	DO51886	BLCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.7031
p.A713S	TCGA-IB-7651	PAAD	TCGA	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.7588
p.A713S	DO46657	PAAD	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.7588
p.I709T	TCGA-RD-A8N6	STAD	TCGA	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.25
p.I709T	DO50140	STAD	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.25
p.T710N	DO10236	COAD	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.2778
p.A704S	DO227709	COCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.A704S	DO229010	COCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.A704S	DO229013	COCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.A704S	DO229016	COCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.A704S	DO229003	COCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.A704S	DO229489	LAML	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.A704S	DO228947	LICA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.A704S	DO230999	LUSC	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.A704S	DO231075	LUSC	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.A704S	DO231007	LUSC	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.S719R	DO228971	LICA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.7427
p.P714S	DO222843	MELA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.6752
p.K730Q	DO41584	UCEC	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1667
p.R718T	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.6765
p.R718T	ACH-000787	Lung Cancer	CCLE	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.6765
p.R718T	LXF-289	lung	COSMIC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.6765
p.S732N	SIDM00479	Esophageal Carcinoma	GDSC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.S732N	ACH-000679	Esophageal Cancer	CCLE	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.S732N	OE19	oesophagus	COSMIC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.R720S	ACH-002044	Head and Neck Cancer	CCLE	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.6316

Kaplan plot for EIF2AK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EIF2AK3

UniProt ID: Q9NZJ5

Entrez ID: 9451

Protein name: Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EIF2AK3 in