DegronMD

Uniprot ID: Q9NZJ5

Source protein: Eukaryotic translation initiation factor 2-alpha kinase 3

Source gene: EIF2AK3

Class: DEG_ODPH_VHL_1

Location: 712:724

E3 ligase: VHL

DEGRON score: 0.9979

ASA_SCORE: 62.2462

COIL: 0.7042

CONS_SCORE: 0.2483

DSS_SCORE: 0.5137

HELIX: 0.0928

FCONS_SCORE: 1.0283

RIG_SCORE: 0.6902

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P716L	TCGA-D3-A8GM	SKCM	TCGA	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.6471
p.P716L	SIDM00209	Glioblastoma	GDSC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.6471
p.P716L	D-423MG	central_nervous_system	COSMIC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.6471
p.T705K	TCGA-D7-6528	STAD	TCGA	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.5833
p.P714T	TCGA-GD-A76B	BLCA	TCGA	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.7031
p.P714T	DO51886	BLCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.7031
p.A713S	TCGA-IB-7651	PAAD	TCGA	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.7588
p.A713S	DO46657	PAAD	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.7588
p.I709T	TCGA-RD-A8N6	STAD	TCGA	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.25
p.I709T	DO50140	STAD	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.25
p.T710N	DO10236	COAD	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.2778
p.A704S	DO227709	COCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.A704S	DO229010	COCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.A704S	DO229013	COCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.A704S	DO229016	COCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.A704S	DO229003	COCA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.A704S	DO229489	LAML	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.A704S	DO228947	LICA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.A704S	DO230999	LUSC	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.A704S	DO231075	LUSC	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.A704S	DO231007	LUSC	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.S719R	DO228971	LICA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.7427
p.P714S	DO222843	MELA	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.6752
p.K730Q	DO41584	UCEC	ICGC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1667
p.R718T	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.6765
p.R718T	ACH-000787	Lung Cancer	CCLE	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.6765
p.R718T	LXF-289	lung	COSMIC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.6765
p.S732N	SIDM00479	Esophageal Carcinoma	GDSC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.S732N	ACH-000679	Esophageal Cancer	CCLE	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.S732N	OE19	oesophagus	COSMIC	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.1111
p.R720S	ACH-002044	Head and Neck Cancer	CCLE	IAPSPQRSRSFSV	DEG_ODPH_VHL_1	0.6316

Drug responses associated with EIF2AK3 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.E994A (No)	GDSC	GSK2606414	22.287
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.A1068V (No)	GDSC	GSK2606414	8.4809
SIDM00683	PRAD\|prostate	p.M1053V (No)	GDSC	GSK2606414	29.723
SIDM00901	UCEC\|endometrium	p.Y1019C (No)	GDSC	GSK2606414	7.2928
SIDM00849	KIRC\|kidney	p.A422T (No)	GDSC	GSK2606414	39.591
SIDM00264	UNCLASSIFIED\|ewings_sarcoma	p.D307E (No)	GDSC	GSK2606414	283.2
SIDM01093	CESC\|cervix	p.I310L (No)	GDSC	GSK2606414	49.106
SIDM01190	BLCA\|bladder	p.R240H (No)	GDSC	GSK2606414	105.86
SIDM00980	STAD\|stomach	p.I906V (No)	GDSC	GSK2606414	23.581
SIDM00499	PRAD\|prostate	p.R911fs*20 (No)	GDSC	GSK2606414	28.045
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.N582fs*11 (No)	GDSC	GSK2606414	8.4809
SIDM00490	GBM\|glioma	p.M975fs*30 (No)	GDSC	GSK2606414	84.494
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.E86fs*18 (No)	GDSC	GSK2606414	9.3974
SIDM01045	UCEC\|endometrium	p.L181H (No)	GDSC	GSK2606414	51.389
SIDM00217	COREAD\|large_intestine	p.Q887* (No)	GDSC	GSK2606414	29.356
SIDM00217	COREAD\|large_intestine	p.V568A (No)	GDSC	GSK2606414	29.356
SIDM00839	COREAD\|large_intestine	p.G327* (No)	GDSC	GSK2606414	22.919
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.R240H (No)	GDSC	GSK2606414	109.12
SIDM00282	COREAD\|large_intestine	p.A342V (No)	GDSC	GSK2606414	24.257
SIDM00479	ESCA\|oesophagus	p.S732N (Yes)	GDSC	GSK2606414	246.58
SIDM00479	ESCA\|oesophagus	p.N478H (No)	GDSC	GSK2606414	246.58
SIDM00150	COREAD\|large_intestine	p.D691N (No)	GDSC	GSK2606414	2.3859
SIDM00660	COREAD\|large_intestine	p.S1022N (No)	GDSC	GSK2606414	78.225
SIDM00660	COREAD\|large_intestine	p.P1020Q (No)	GDSC	GSK2606414	78.225
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.Q667K (No)	GDSC	GSK2606414	61.874
SIDM00267	UNCLASSIFIED\|biliary_tract	p.E372K (No)	GDSC	GSK2606414	38.03
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.E820* (No)	GDSC	GSK2606414	65.9
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.M390L (No)	GDSC	GSK2606414	16.95
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.V132M (No)	GDSC	GSK2606414	11.272
SIDM00282	COREAD\|large_intestine	p.K635fs*2 (No)	GDSC	GSK2606414	24.257
SIDM01169	OV\|ovary	p.A116D (No)	GDSC	GSK2606414	17.01
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.I917N (No)	GDSC	GSK2606414	46.941
SIDM00541	COREAD\|large_intestine	p.T428A (No)	GDSC	GSK2606414	11.348
SIDM00541	COREAD\|large_intestine	p.R240H (No)	GDSC	GSK2606414	11.348
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R240H (No)	GDSC	GSK2606414	13.986
SIDM00119	LUAD\|lung_NSCLC_adenocarcinoma	p.A342D (No)	GDSC	GSK2606414	51.837
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.Y186H (No)	GDSC	GSK2606414	201.94
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.R718T (Yes)	GDSC	GSK2606414	16.682
SIDM00921	LUAD\|lung_NSCLC_adenocarcinoma	p.L827S (No)	GDSC	GSK2606414	31.732
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.A468S (No)	GDSC	GSK2606414	8.3449
SIDM01259	ALL\|lymphoblastic_leukemia	p.E967G (No)	GDSC	GSK2606414	13.117
SIDM00537	COREAD\|large_intestine	p.D777E (No)	GDSC	GSK2606414	30.835
SIDM00384	DLBC\|B_cell_lymphoma	p.D357N (No)	GDSC	GSK2606414	15.776
SIDM00054	PAAD\|pancreas	p.Q558E (No)	GDSC	GSK2606414	59.394
SIDM00364	ALL\|lymphoblastic_leukemia	p.R911fs*20 (No)	GDSC	GSK2606414	8.3465
SIDM00113	KIRC\|kidney	p.F335V (No)	GDSC	GSK2606414	236.81
SIDM00878	BRCA\|breast	p.M1053V (No)	GDSC	GSK2606414	44.466
SIDM00971	BRCA\|breast	p.D366delD (No)	GDSC	GSK2606414	61.802
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E1050K (No)	GDSC	GSK2606414	15.227
SIDM00118	COREAD\|large_intestine	p.E809* (No)	GDSC	GSK2606414	54.103

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPSPQRSRSFSV

Degron related mutations and impact score

Drug responses associated with EIF2AK3 mutations

All proteins holding degron of IAPSPQRSRSFSV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZJ5	Eukaryotic translation initiation factor 2-alpha kinase 3	DEG_ODPH_VHL_1	712:724	IAPSPQRSRSFSV	VHL	0.9979	More...