ADA2
UniProt ID: Q9NZK5
Entrez ID: 51816
Protein name: Adenosine deaminase 2 (EC 3.5.4.4) (Cat eye syndrome critical region protein 1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the reg...
FUNCTION: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. {ECO:0000269|PubMed:20147294, ECO:0000269|PubMed:20453107}.
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GO - Biological processes (BP):
adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103]...
adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103]
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GO - Molecular function (MF):
adenosine deaminase activity [GO:0004000]; adenosine receptor binding [GO:0031685]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; zinc ion binding [GO:0008270]...
adenosine deaminase activity [GO:0004000]; adenosine receptor binding [GO:0031685]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; zinc ion binding [GO:0008270]
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GO - Cellular component (CC):
azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; extracellular space [GO:0005615]...
azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]; extracellular space [GO:0005615]
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ADA2
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Kaplan plot for ADA2 in
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*NOTE: the Kaplan plots were collected from OncoLnc