DegronMD

Uniprot ID: Q9NZK5

Source protein: Adenosine deaminase 2

Source gene: ADA2

Class: DEG_SCF_FBW7_1

Location: 151:156

E3 ligase: FBXW7

DEGRON score: 0.8579

ASA_SCORE: 83.9

COIL: 0.924

CONS_SCORE: 0.2911

DSS_SCORE: 0.2085

HELIX: 0.0325

FCONS_SCORE: 0.8018

RIG_SCORE: 0.7081

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H150Q	HOS	bone	COSMIC	PTPRPS	DEG_SCF_FBW7_1	0.3056
p.K147N	LS-1034	large_intestine	COSMIC	PTPRPS	DEG_SCF_FBW7_1	0.2222
p.Q158K	MDST8	large_intestine	COSMIC	PTPRPS	DEG_SCF_FBW7_1	0.2778
p.K155N	HT-115	large_intestine	COSMIC	PTPRPS	DEG_SCF_FBW7_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZK5	Adenosine deaminase 2	DEG_SCF_FBW7_1	151:156	PTPRPS	FBXW7	0.8579	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons