DegronMD - Q9NZN4(EHD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D428N	TCGA-EY-A215	UCEC	TCGA	MGPFVE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.2222
p.V409G	DO48405	BLCA	ICGC	MGPFVE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.0556
p.P421L	SIDM01164	Glioma	GDSC	MGPFVE	LIG_APCC_ABBA_1	419:424	Mutation altering degron motif	0.6471
p.P421L	ACH-000883	Brain Cancer	CCLE	MGPFVE	LIG_APCC_ABBA_1	419:424	Mutation altering degron motif	0.6471
p.P421L	SW1783	central nervous system	COSMIC	MGPFVE	LIG_APCC_ABBA_1	419:424	Mutation altering degron motif	0.6471
p.V409M	SIDM00431	T-Lymphoblastic Leukemia	GDSC	MGPFVE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.0556
p.V409M	ACH-000918	Leukemia	CCLE	MGPFVE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.0556
p.V409M	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	MGPFVE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.0556
p.G412R	SIDM00289	B-Lymphoblastic Leukemia	GDSC	MGPFVE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1389
p.G412R	ACH-002241	Leukemia	CCLE	MGPFVE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1389
p.G412R	HAL-01	haematopoietic and lymphoid tissue	COSMIC	MGPFVE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons