DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MGPFVE
Uniprot ID:
Q9NZN4
Source protein:
EH domain-containing protein 2
Source gene:
EHD2
Class:
LIG_APCC_ABBA_1
Location:
419:424
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9928
ASA_SCORE:
63.6
COIL:
0.7095
CONS_SCORE:
0.3434
DSS_SCORE:
0.6887
HELIX:
0.0657
FCONS_SCORE:
1.2759
RIG_SCORE:
0.6972
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D428N
TCGA-EY-A215
UCEC
TCGA
MGPFVE
LIG_APCC_ABBA_1
0.2222
p.V409G
DO48405
BLCA
ICGC
MGPFVE
LIG_APCC_ABBA_1
0.0556
p.P421L
SIDM01164
Glioma
GDSC
MGPFVE
LIG_APCC_ABBA_1
0.6471
p.P421L
ACH-000883
Brain Cancer
CCLE
MGPFVE
LIG_APCC_ABBA_1
0.6471
p.P421L
SW1783
central_nervous_system
COSMIC
MGPFVE
LIG_APCC_ABBA_1
0.6471
p.V409M
SIDM00431
T-Lymphoblastic Leukemia
GDSC
MGPFVE
LIG_APCC_ABBA_1
0.0556
p.V409M
ACH-000918
Leukemia
CCLE
MGPFVE
LIG_APCC_ABBA_1
0.0556
p.V409M
MOLT-16
haematopoietic_and_lymphoid_tissue
COSMIC
MGPFVE
LIG_APCC_ABBA_1
0.0556
p.G412R
SIDM00289
B-Lymphoblastic Leukemia
GDSC
MGPFVE
LIG_APCC_ABBA_1
0.1389
p.G412R
ACH-002241
Leukemia
CCLE
MGPFVE
LIG_APCC_ABBA_1
0.1389
p.G412R
HAL-01
haematopoietic_and_lymphoid_tissue
COSMIC
MGPFVE
LIG_APCC_ABBA_1
0.1389
Drug responses associated with EHD2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MGPFVE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NZN4
EH domain-containing protein 2
LIG_APCC_ABBA_1
419:424
MGPFVE
APC,CDC20,FZR1
0.9928
More...