DegronMD - Q9NZV1(CRIM1)

FUNCTION: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. {ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}.

GO - Biological processes (BP): negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoblast differentiation [GO:0045668]; nervous system development [GO:0007399]

GO - Molecular function (MF): insulin-like growth factor-activated receptor activity [GO:0005010]; PDZ domain binding [GO:0030165]; serine-type endopeptidase inhibitor activity [GO:0004867]

GO - Cellular component (CC): extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R314C	TCGA-CV-7411	HNSC	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation altering degron motif	0.719
p.R314C	DO15142	HNSC	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation altering degron motif	0.719
p.R314H	SIDM00487	Colorectal Carcinoma	GDSC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation altering degron motif	0.7133
p.R314H	ACH-000963	Colon/Colorectal Cancer	CCLE	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation altering degron motif	0.7133
p.R314H	CCK-81	large intestine	COSMIC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation altering degron motif	0.7133
p.G320V	TCGA-AX-A2HC	UCEC	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation altering degron motif	0.6421
p.G320V	DO41572	UCEC	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation altering degron motif	0.6421
p.G315V	TCGA-D9-A148	SKCM	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation altering degron motif	0.6421
p.G315V	DO37971	SKCM	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation altering degron motif	0.6421
p.S313C	TCGA-ZG-A9NI	PRAD	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation rewiring degron network	0.3056
p.S313C	DO219448	PRAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation rewiring degron network	0.3056
p.C322F	SIDM00836	Colorectal Carcinoma	GDSC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation rewiring degron network	0.3056
p.C322F	ACH-000820	Colon/Colorectal Cancer	CCLE	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation rewiring degron network	0.3056
p.C322F	SW403	large intestine	COSMIC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation rewiring degron network	0.3056
p.C323F	TCGA-95-7043	LUAD	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation rewiring degron network	0.2778
p.C323F	DO24739	LUAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation rewiring degron network	0.2778
p.I311L	TCGA-LN-A7HY	ESCA	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation rewiring degron network	0.25
p.R310H	TCGA-78-7152	LUAD	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation rewiring degron network	0.2222
p.R310H	DO234254	ESAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation rewiring degron network	0.2222
p.R310H	DO23560	LUAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	314:321	Mutation rewiring degron network	0.2222

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

CRIM1

UniProt ID: Q9NZV1

Entrez ID: 51232

Protein name: Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CRIM1 in