DegronMD

Uniprot ID: Q9NZV1

Source protein: Cysteine-rich motor neuron 1 protein

Source gene: CRIM1

Class: DEG_SCF_SKP2-CKS1_1

Location: 314:321

E3 ligase: SKP2,CSK1

DEGRON score: 0.6292

ASA_SCORE: 77.0125

COIL: 0.8164

CONS_SCORE: 0.767

DSS_SCORE: 0.108

HELIX: 0.0305

FCONS_SCORE: 1.153

RIG_SCORE: 0.7094

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R314C	TCGA-CV-7411	HNSC	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.719
p.R314C	DO15142	HNSC	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.719
p.R314H	SIDM00487	Colorectal Carcinoma	GDSC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.7133
p.R314H	ACH-000963	Colon/Colorectal Cancer	CCLE	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.7133
p.R314H	CCK-81	large_intestine	COSMIC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.7133
p.G320V	TCGA-AX-A2HC	UCEC	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.6421
p.G320V	DO41572	UCEC	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.6421
p.G315V	TCGA-D9-A148	SKCM	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.6421
p.G315V	DO37971	SKCM	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.6421
p.S313C	TCGA-ZG-A9NI	PRAD	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.3056
p.S313C	DO219448	PRAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.3056
p.C322F	SIDM00836	Colorectal Carcinoma	GDSC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.3056
p.C322F	ACH-000820	Colon/Colorectal Cancer	CCLE	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.3056
p.C322F	SW403	large_intestine	COSMIC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.3056
p.C323F	TCGA-95-7043	LUAD	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.C323F	DO24739	LUAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.I311L	TCGA-LN-A7HY	ESCA	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.R310H	TCGA-78-7152	LUAD	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R310H	DO234254	ESAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R310H	DO23560	LUAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R310C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R310C	ACH-000953	Leukemia	CCLE	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R310C	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P309S	TCGA-EE-A29E	SKCM	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P309S	DO37831	SKCM	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.1944

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Drug responses associated with CRIM1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of RGDGTPGK

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZV1	Cysteine-rich motor neuron 1 protein	DEG_SCF_SKP2-CKS1_1	314:321	RGDGTPGK	SKP2,CSK1	0.6292	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RGDGTPGK

Degron related mutations and impact score

Drug responses associated with CRIM1 mutations

All proteins holding degron of RGDGTPGK