DegronMD

Uniprot ID: Q9NZV1

Source protein: Cysteine-rich motor neuron 1 protein

Source gene: CRIM1

Class: DEG_SCF_SKP2-CKS1_1

Location: 314:321

E3 ligase: SKP2,CSK1

DEGRON score: 0.6292

ASA_SCORE: 77.0125

COIL: 0.8164

CONS_SCORE: 0.767

DSS_SCORE: 0.108

HELIX: 0.0305

FCONS_SCORE: 1.153

RIG_SCORE: 0.7094

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R310H	TCGA-78-7152	LUAD	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R310H	DO234254	ESAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R310H	DO23560	LUAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.C323F	TCGA-95-7043	LUAD	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.C323F	DO24739	LUAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.G320V	TCGA-AX-A2HC	UCEC	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.6421
p.G320V	DO41572	UCEC	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.6421
p.R314C	TCGA-CV-7411	HNSC	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.719
p.R314C	DO15142	HNSC	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.719
p.G315V	TCGA-D9-A148	SKCM	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.6421
p.G315V	DO37971	SKCM	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.6421
p.P309S	TCGA-EE-A29E	SKCM	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P309S	DO37831	SKCM	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.1944
p.I311L	TCGA-LN-A7HY	ESCA	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.E327Q	TCGA-VQ-AA64	STAD	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E327Q	DO222381	STAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.S313C	TCGA-ZG-A9NI	PRAD	TCGA	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.3056
p.S313C	DO219448	PRAD	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.3056
p.V329F	DO229022	LICA	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.D331Y	DO229036	LICA	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.D331Y	DO229037	LICA	ICGC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R310C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R310C	ACH-000953	Leukemia	CCLE	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R310C	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R314H	SIDM00487	Colorectal Carcinoma	GDSC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.7133
p.R314H	ACH-000963	Colon/Colorectal Cancer	CCLE	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.7133
p.R314H	CCK-81	large_intestine	COSMIC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.7133
p.C322F	SIDM00836	Colorectal Carcinoma	GDSC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.3056
p.C322F	ACH-000820	Colon/Colorectal Cancer	CCLE	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.3056
p.C322F	SW403	large_intestine	COSMIC	RGDGTPGK	DEG_SCF_SKP2-CKS1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RGDGTPGK

Degron related mutations and impact score

Drug responses associated with CRIM1 mutations

All proteins holding degron of RGDGTPGK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZV1	Cysteine-rich motor neuron 1 protein	DEG_SCF_SKP2-CKS1_1	314:321	RGDGTPGK	SKP2,CSK1	0.6292	More...