DegronMD - Q9NZW4(DSPP)

DSPP

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G545C	TCGA-A5-A0G2	UCEC	TCGA	DSGKGKS	DEG_SCF_TRCP1_1	541:547	Mutation altering degron motif	0.6489
p.G545C	DO41235	UCEC	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	541:547	Mutation altering degron motif	0.6489
p.S549N	TCGA-A6-6780	COAD	TCGA	DSGKGKS	DEG_SCF_TRCP1_1	541:547	Mutation blocking phosphorylation signal	0.7222
p.S549N	DO10244	COAD	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	541:547	Mutation blocking phosphorylation signal	0.7222
p.G543V	TCGA-AZ-4315	COAD	TCGA	DSGKGKS	DEG_SCF_TRCP1_1	541:547	Mutation altering degron motif	0.7532
p.G543V	DO8842	COAD	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	541:547	Mutation altering degron motif	0.7532
p.D536G	TCGA-BR-6802	STAD	TCGA	DSGKGKS	DEG_SCF_TRCP1_1	541:547	Mutation rewiring degron network	0.1944
p.D536G	DO38332	STAD	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	541:547	Mutation rewiring degron network	0.1944
p.K539T	DO222762	COCA	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	541:547	Mutation rewiring degron network	0.2778
p.S550G	DO234259	ESAD	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	541:547	Mutation blocking phosphorylation signal	0.6944

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*NOTE: the Kaplan plots were collected from OncoLnc