DegronMD

Uniprot ID: Q9NZW4

Source protein: Dentin sialophosphoprotein [Cleaved into: Dentin phosphoprotein

Source gene: DSPP

Class: DEG_SCF_TRCP1_1

Location: 541:547

E3 ligase: BTRC

DEGRON score: 0.956

ASA_SCORE: 101.1143

COIL: 0.9609

CONS_SCORE: 0.4665

DSS_SCORE: 0.687

HELIX: 0.0273

FCONS_SCORE: 0.9489

RIG_SCORE: 0.481

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G545C	TCGA-A5-A0G2	UCEC	TCGA	DSGKGKS	DEG_SCF_TRCP1_1	0.6489
p.G545C	DO41235	UCEC	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	0.6489
p.S549N	TCGA-A6-6780	COAD	TCGA	DSGKGKS	DEG_SCF_TRCP1_1	0.7222
p.S549N	DO10244	COAD	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	0.7222
p.G543V	TCGA-AZ-4315	COAD	TCGA	DSGKGKS	DEG_SCF_TRCP1_1	0.7532
p.G543V	DO8842	COAD	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	0.7532
p.D536G	TCGA-BR-6802	STAD	TCGA	DSGKGKS	DEG_SCF_TRCP1_1	0.1944
p.D536G	DO38332	STAD	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	0.1944
p.K539T	DO222762	COCA	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	0.2778
p.S550G	DO234259	ESAD	ICGC	DSGKGKS	DEG_SCF_TRCP1_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZW4	Dentin sialophosphoprotein [Cleaved into: Dentin phosphoprotein	DEG_SCF_TRCP1_1	541:547	DSGKGKS	BTRC	0.956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons