DegronMD - Q9P015(MRPL15)

MRPL15

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K34N	TCGA-CA-6717	COAD	TCGA	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation substituting flanking lysine	0.2778
p.K34N	DO8264	COAD	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation substituting flanking lysine	0.2778
p.K34N	DO233751	GACA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation substituting flanking lysine	0.2778
p.R11W	TCGA-IE-A6BZ	SARC	TCGA	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0833
p.R11W	DO220159	SARC	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0833
p.E37D	DO224847	BRCA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0833
p.E37D	DO227473	BRCA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0833
p.E37D	DO229015	LICA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0833
p.G18D	DO222427	BTCA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.2778
p.V22L	DO229025	LICA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation altering degron motif	0.5654
p.D14Y	DO229024	LICA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1667
p.P31S	ACH-000545	Bladder Cancer	CCLE	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.25
p.L13M	ACH-000990	Endometrial/Uterine Cancer	CCLE	PRVSLANLK	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc