DegronMD

Uniprot ID: Q9P015

Source protein: 39S ribosomal protein L15, mitochondrial

Source gene: MRPL15

Class: DEG_APCC_DBOX_1

Location: 20:28

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.927

ASA_SCORE: 57.5556

COIL: 0.5987

CONS_SCORE: 0.4403

DSS_SCORE: 0.5978

HELIX: 0.2597

FCONS_SCORE: 1.1166

RIG_SCORE: 0.7031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K34N	TCGA-CA-6717	COAD	TCGA	PRVSLANLK	DEG_APCC_DBOX_1	0.2778
p.K34N	DO8264	COAD	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	0.2778
p.K34N	DO233751	GACA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	0.2778
p.R11W	TCGA-IE-A6BZ	SARC	TCGA	PRVSLANLK	DEG_APCC_DBOX_1	0.0833
p.R11W	DO220159	SARC	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	0.0833
p.E37D	DO224847	BRCA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	0.0833
p.E37D	DO227473	BRCA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	0.0833
p.E37D	DO229015	LICA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	0.0833
p.G18D	DO222427	BTCA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	0.2778
p.V22L	DO229025	LICA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	0.5654
p.D14Y	DO229024	LICA	ICGC	PRVSLANLK	DEG_APCC_DBOX_1	0.1667
p.P31S	ACH-000545	Bladder Cancer	CCLE	PRVSLANLK	DEG_APCC_DBOX_1	0.25
p.L13M	ACH-000990	Endometrial/Uterine Cancer	CCLE	PRVSLANLK	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P015	39S ribosomal protein L15, mitochondrial	DEG_APCC_DBOX_1	20:28	PRVSLANLK	APC,CDC20,FZR1	0.927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons